Heterochromatin silencing and locus repositioning linked to regulation of virulence genes in <em>Plasmodium falciparum</em> (Publications)
The malaria parasite Plasmodium falciparum undergoes antigenic variation to evade host immune responses through switching expression of variant surface proteins encoded by the var gene family. We demonstrate
Estimation of the antirelapse efficacy of tafenoquine, using <em>Plasmodium vivax</em> genotyping (Publications)
Plasmodium vivax relapse prevention is a key treatment goal in malaria. Use of P. vivax genotyping in a multicenter, double-blind, randomized, placebo-controlled Phase IIb study in Peru, India, Thailand
Novel nucleoside-based antimalarial compounds (Publications)
The malaria-causing parasite Plasmodium falciparum employs a salvage pathway for the biosynthesis of nucleotides, in contrast to de novo biosynthesis that is utilized by the human host. A series of twenty-two
Antiplasmodial activity of a series of 1,3,5-triazine-substituted polyamines (Publications)
some parasitic protozoa and it is proposed that the pathway might also represent a target in the malaria parasite Plasmodium falciparum. A series of 1,3,5-triazine-substituted polyamine analogues were tested
Mar Velarde (People)
https://www.swisstph.ch/de/staff/profile/people/mar-velarde
worked for two different departments within the World Health Organization (WHO), namely the Global Malaria Programme and the Department of Neglected Tropical Diseases. Since 2018, Mar has been working at
Ecosystem Health Sciences | Research at Swiss TPH (Page)
https://www.swisstph.ch/de/about/eph/ecosystem-health-sciences
is on neglected tropical diseases (NTDs), particularly those caused by parasitic worm infections, malaria and water related diseases. The main areas of investigation include metabolic profiling, health impact [...] projects in complex eco-epidemiological settings, and epidemiology and integrated control of NTDs and malaria. WHO Collaborating Centre for Epidemiology and Control of Helminth Infections Groups Ecosystem Services [...] on the health of population. Côte d'Ivoire faces increasing...
Diseases and Programmes | Swiss TPH (Page)
https://www.swisstph.ch/de/about/scih/diseases-and-programmes
(ESHIA) in Burkina Faso on the use of genetically modified mosquitoes (GMMs) for future malaria control. Target Malaria - a vector control research collaborative based at Imperial College, London - aims to [...] evaluations; and (iii) poverty-related diseases such as Neglected Tropical Diseases, tuberculosis and malaria. From validation to application and health impact assessment We pay particular attention to “access” [...] to develop genetic technologies to modify mosquitoes to ultimately...
«Ich bin überzeugt, dass Pharmaunternehmen mehr tun können, als Medikamente herstellen» (Page)
https://www.swisstph.ch/de/impact-stories/i-believe-that-pharmaceutical-companies-can-do-more-than-providing-medicines
Ländern mit niedrigem und mittlerem Einkommen auf den Markt. Wir befassen uns mit Krankheiten wie Malaria, Leishmaniose und Dengue-Fieber, von denen vor allem ärmere Länder und vulnerable Bevölkerungsgruppen [...] . Wir können die Herausforderungen von morgen nicht mit den Mitteln von gestern bewältigen. Bei Malaria, gegen die seit 25 Jahren kein neues Medikament mehr entwickelt wurde, nimmt die Arzneimittelresistenz [...] die wir als globale Gemeinschaft im Kampf gegen Lepra erzielt haben, oder...
Impact Stories | Swiss TPH (Page)
https://www.swisstph.ch/de/impact-stories
research. Mehr erfahren 22.04.2021 Julia Richter, Swiss Malaria Group World Malaria Day 2021: In the shadows of the COVID-19 pandemic A world without malaria is within reach. At the same time, the COVID-19 pandemic [...] progress in the fight against malaria. This year's World Malaria Day on 25 April 2021 will draw attention to the fact that further efforts are needed to achieve the goal of a malaria-free world. Mehr erfahren [...] years, much has been invested in malaria prevention and...
Adherence to standard treatment guidelines among prescribers in primary healthcare facilities in the Dodoma region of Tanzania (Publications)
in 2872 cases. The nine most prevalent conditions were upper respiratory tract infections (25%), malaria (18%), diarrhoea (9.9%), pneumonia (6.1%), skin problems (5.8%), gastrointestinal diagnoses (5%) [...] of cases that did not adhere to STG was highest with patients with skin problems and lowest for malaria. Conclusion: Prescribers' general adherence to national STG in primary HCF in the public sector in