Aquaporin 2 mutations in <em>Trypanosoma brucei gambiense</em> field isolates correlate with decreased susceptibility to pentamidine and melarsoprol (Publications)
The predominant mechanism of drug resistance in African trypanosomes is decreased drug uptake due to loss-of-function mutations in the genes for the transporters that mediate drug import. The role of
Long-term dominance of <em>Mycobacterium tuberculosis</em> Uganda family in peri-urban Kampala-Uganda is not associated with cavitary disease (Publications)
BACKGROUND: Previous studies have shown that Mycobacterium tuberculosis (MTB) Uganda family, a sub-lineage of the MTB Lineage 4, is the main cause of tuberculosis (TB) in Uganda. Using a well characte
Comparing sociocultural features of cholera in three endemic African settings (Publications)
BACKGROUND: Cholera mainly affects developing countries where safe water supply and sanitation infrastructure are often rudimentary. Sub-Saharan Africa is a cholera hotspot. Effective cholera control
Ownership and usage of mosquito nets after four years of large-scale free distribution in Papua New Guinea (Publications)
BACKGROUND: Papua New Guinea (PNG) is a highly malaria endemic country in the South-West Pacific with a population of approximately 6.6 million (2009). In 2004, the country intensified its malaria con
Effects of hygiene and defecation behavior on helminths and intestinal protozoa infections in Taabo, Côte d'Ivoire (Publications)
BACKGROUND: More than 1 billion people are currently infected with soil-transmitted helminths and schistosomes. The global strategy to control helminthiases is the regular administration of anthelmint
Development of an<em> in vitro</em> drug sensitivity assay based on newly excysted larvae of <em>Echinostoma caproni</em> (Publications)
BACKGROUND: Echinostomiasis is one of the major food-borne trematodiases and the species Echinostoma caproni serves as a useful model for trematocidal drug discovery. The current in vitro drug sensiti
