Status of insecticide resistance in Papua New Guinea: an update from nation-wide monitoring of anopheles mosquitoes (Publications)
distribution of insecticide-treated nets. Here, we provide an update on phenotypic IR in four highly malaria-endemic areas of PNG. IR against deltamethrin, lambda-cyhalothrin, and dichlorodiphenyltrichloroethane
Conformational aspects in the design of inhibitors for serine hydroxymethyltransferase (SHMT): biphenyl, aryl sulfonamide, and aryl sulfone motifs (Publications)
Malaria remains a major threat to mankind due to the perpetual emergence of resistance against marketed drugs. Twenty-one pyrazolopyran-based inhibitors bearing terminal biphenyl, aryl sulfonamide, or
The adjuvant GLA-SE promotes human Tfh cell expansion and emergence of public TCRβ clonotypes (Publications)
vaccine formulations, circulating Tfh cells were expanded in Tanzanian volunteers when an experimental malaria vaccine was adjuvanted in GLA-SE but not when formulated in Alum. The GLA-SE-formulated peptide was
A <em>Plasmodium </em>membrane receptor platform integrates cues for egress and invasion in blood forms and activation of transmission stages (Publications)
Critical events in the life cycle of malaria-causing parasites depend on cyclic guanosine monophosphate homeostasis by guanylyl cyclases (GCs) and phosphodiesterases, including merozoite egress or invasion
Vector Research and Control (Page)
https://www.swisstph.ch/de/about/eph/vector-biology/vector-research-and-control
Activities Preclinical Research Arthropod Testing Facility Services Related Topics Malaria More to Explore Dynamical Modelling Malaria Initiative Links Antimücken-Sprays im Test (SRF, 2016) Tigermücke im Anflug [...] particularly important vectors as they spread some of the most devastating infectious diseases such as malaria, dengue fever, West Nile fever or Zika virus infections. Investigation of Vectors and Development [...] Study of a Self-Limiting Nondrive Strain of Genetically Modified...
Der Epidemiologe und Gesundheitsexperte Marcel Tanner erhält Ehrendoktorwürde der Universität Zürich (News)
https://www.swisstph.ch/de/news/news-detail-1/news/der-epidemiologe-und-gesundheitsexperte-marcel-tanner-erhaelt-ehrendoktorwuerde-der-universitaet-zuerich
zahlreichen Forschungsarbeiten der Epidemiologie und Bekämpfung infektiöser Krankheiten (vor allem Malaria). Daneben betreute er im Auftrag der DEZA grosse Gesundheitsprogramme und Forschungsprojekte in [...] ländlichen und städtischen Gebieten von Tansania und Tschad. Er war massgeblich an der Entwicklung von Malaria-Impfstoffen (SPf66, RTS,S) für Afrika beteiligt. Von 1996-1997 und 2009-2010 nahm Marcel Tanner
<em>Plasmodium falciparum</em> sexual commitment rate variation among clinical isolates and diverse laboratory-adapted lines (Publications)
Asexual blood-stage malaria parasites must produce sexual progeny to infect mosquitoes. It is important to understand the scope and causes of intraspecific variation in sexual commitment rates, particularly [...] variation of this key reproductive trait that likely affects transmission. IMPORTANCE Only sexual-stage malaria parasites are transmitted from human blood to mosquitoes. Thus, it is vital to understand variations
Comparison of cone bioassay estimates at two laboratories with different <em>Anopheles </em>mosquitoes for quality assurance of pyrethroid... (Publications)
insecticide-treated nets (ITNs) delivered to malaria-endemic countries is conducted by measuring physiochemical parameters, but not bioefficacy against malaria mosquitoes. This study explored utility of
Incidence and consequences of damage to insecticide-treated mosquito nets in Kenya (Publications)
estimated to account for 7-11% of loss in effect on vectorial capacity for Plasmodium falciparum malaria in an analysis of repeated cross-sectional surveys of LLINs in Kenya. This does not account for the [...] nets could substantially increase their lifetime and impact but the impact of LLIN programmes on malaria transmission is ultimately limited by levels of use. Longitudinal analyses of net integrity data
Expression of the MSPDBL2 antigen in a discrete subset of <em>Plasmodium falciparum</em> schizonts is regulated by GDV1 but may not be linked to... (Publications)
requires further investigation in natural infections where it is under immune selection. IMPORTANCE: Malaria parasites in the blood are remarkably variable, able to switch antigenic targets so they may survive [...] developed specific immune responses. This is one of the challenges in developing vaccines against malaria. MSPDBL2 is a target of naturally acquired immunity expressed in minority proportions of schizonts