Optimization of 4-aminoquinoline/clotrimazole-based hybrid antimalarials: further structure-activity relationships, in vivo studies, and preliminary... (Publications)
Despite recent progress in the fight against malaria, the emergence and spread of drug-resistant parasites remains a serious obstacle to the treatment of infections. We recently reported the development
Identification of nuclear proteins that differentially interact with <em>Plasmodium falciparum</em> var gene promoters (Publications)
PfEMP1 is responsible for both antigenic variation and cytoadherence of infected erythrocytes in malaria. Approximately 50 var genes per parasite genome code for this highly polymorphic surface protein
Mosquito nets and the poor: can social marketing redress inequities in access? (Publications)
Treated mosquito nets are a practical malaria control tool. However, implementation of efficient delivery mechanisms remains a challenge. We investigated whether social marketing of treated mosquito nets
Blood schizontocidal and gametocytocidal activity of 3-hydroxy-N'-arylidenepropanehydrazonamides: a new class of antiplasmodial compounds (Publications)
moiety, demonstrated in vivo antiplasmodial activity after oral administration in a P. berghei malaria model, although no complete parasite elimination was achieved with a four-dose regimen. The in vivo
Anti-malarial ozonides OZ439 and OZ609 tested at clinically relevant compound exposure parameters in a novel ring-stage survival assay (Publications)
BACKGROUND: Drug efficacy against kelch 13 mutant malaria parasites can be determined in vitro with the ring-stage survival assay (RSA). The conventional assay protocol reflects the exposure profile of
Helen Prytherch (People)
https://www.swisstph.ch/de/staff/profile/people/helen-prytherch
(GIZ), Swiss Agency for Development and Cooperation, World Health Organization and the Roll Back Malaria Partnership.
Monica Golumbeanu (People)
https://www.swisstph.ch/de/staff/profile/people/monica-golumbeanu
her research focuses on developing data-driven computational analyses and mathematical models of malaria infection dynamics to assess the impact of interventions on host and parasite populations. Previously
Klaus Reither (People)
https://www.swisstph.ch/de/staff/profile/people/klaus-reither
Medical Research Programme, Tanzania/LMU Munich, Germany 2005-2006 Study Coordinator. Northern Region Malaria Project, Ghana/Charité Berlin - Other 1993 - 2005 Internal Medicine and Radiology
Diagnostik: Methoden und Material (Page)
https://www.swisstph.ch/de/activities/diagnostic-centre/methods-and-materials
nachgewiesen werden, weshalb die Serologie zur Diagnose einer akuten Malaria ungeeignet ist. Differenzierung verschiedener Malaria-Arten serologisch nicht möglich. Antikörper können Monate bis Jahre p [...] akkreditiert. Plasmodium spp. (Malaria) Methode: Screening real-time PCR mit anschliessender Differenzierung aller humanpathogene Plasmodium Arten ( P. falciparum, P. vivax, P. malariae, P. ovale, P. knowlesi [...] Sensitivität auf ca. 60% sinkt. Spezifität: Kreuzreaktionen möglich mit...
Socio-cultural factors explaining timely and appropriate use of health facilities for degedege in south-eastern Tanzania (Publications)
BACKGROUND: Convulsions is one of the key signs of severe malaria among children under five years of age, potentially leading to serious complications or death. Several studies of care-seeking behaviour [...] that facilities did not provide diagnosis. CONCLUSION: The findings from this sample from a highly malaria-endemic area give support to the more recent studies showing that children with convulsions are more