Antiplasmodial and antitrypanosomal activity of new esters and ethers of 4-dialkylaminobicyclo[2.2.2]octan-2-ols (Publications)
suffer from painful application, severe side effects and increasing resistance against these drugs. Malaria tropica kills more than 2 million people every year mainly due to growing drug resistance. 4-Dia
Solid phase synthesis and antiprotozoal evaluation of di- and trisubstituted 5'-carboxamidoadenosine analogues (Publications)
rapid increase of resistance to drugs commonly used in the treatment of tropical diseases such as malaria and African sleeping sickness calls for the prompt development of new safe and efficacious drugs
Bifurcatriol, a new antiprotozoal acyclic diterpene from the brown alga <em>Bifurcaria bifurcata</em> (Publications)
donovani) and cytotoxicity against mammalian primary cells. The highest activity was exerted against the malaria parasite P. falciparum (IC50 value 0.65 mug/mL) with low cytotoxicity (IC50 value 56.6 mug/mL). To
Indole and benzimidazole bichalcophenes: synthesis, DNA binding and antiparasitic activity (Publications)
their antimicrobial activity against the tropical parasites causing African sleeping sickness and malaria. The dicyanoindoles needed to synthesize the target diamidines were obtained through Stille coupling
Predictors of residual antimalarial drugs in the blood in community surveys in Tanzania (Publications)
cross-sectional survey was conducted in 2015 in three regions of Tanzania with different levels of malaria endemicity. Interviews were conducted and blood samples collected through household surveys for further
Swiss TPH Awarded Four New Research Grants in Paediatric Health (News)
https://www.swisstph.ch/de/news/news-detail-1/news/swiss-tph-awarded-four-new-research-grants-in-paediatric-health
al Nets to Maximise Universal Access Long-lasting insecticidal nets (LLINs) are the mainstay of malaria control. However, more than 50% of people living in endemic areas are currently unprotected because [...] Health Institute and the Ministry of Health in Tanzania will develop a digital tool enabling national malaria control programs to improve planning for programmatic LLIN distribution, monitoring of LLIN quality [...] mosquito net lifespan will optimise resource use, increase the protection...
Clinical TB Research (Page)
https://www.swisstph.ch/de/about/med/clinical-research/clinical-tb-research
Lambiris M.J et al. Health system readiness and the implementation of rectal artesunate for severe malaria in sub-Saharan Africa: an analysis of real-world costs and constraints. Lancet Glob Health . 2023(in [...] 1016/S2214-109X(22)00507-1 Awor P et al. Acceptability of pre-referral rectal artesunate for severe malaria in children under 5 years by health workers and caregivers in the Democratic Republic of the Congo [...] et al. Prereferral rectal artesunate and referral completion among...
Systems Performance and Monitoring (Page)
https://www.swisstph.ch/de/about/scih/systems-performance-and-monitoring
AIDS, Tuberculosis and Malaria created in 2002 to significantly increase resources to fight the three of the world's most devastating diseases (HIV and AIDS, Tuberculosis, and Malaria), and to direct those [...] L.F, Abdallah A.K, Galli F, Canavan R, Molesworth K. Knowledge, attitudes and practices towards malaria diagnostics among healthcare providers and healthcare-seekers in Kondoa district, Tanzania: a mu
A project testing whether small solar powered electric fans improve comfort inside mosquito nets (Projects)
https://www.swisstph.ch/de/projects/project-detail/project/a-project-testing-whether-small-solar-powered-electric-fans-improve-comfort-inside-mosquito-nets
Background Long-lasting insecticidal nets (LLINs) are ineffective malaria transmission prevention tools if they are unused. Discomfort due to heat is the most commonly reported reason for not using nets [...] price of solar power, fans could improve comfort inside nets and be affordable to populations in malaria endemic areas. Here, results are presented from a pilot randomized controlled cross-over study testing
<em>In vitro</em> antiplasmodial activity and cytotoxicity of extracts and chromatographic fractions of twigs from <em>Pappea capensi</em>s EckI &... (Publications)
The Vha-Venda people of South Africa use Pappea capensis EckI & Zeyh. (Sapindaceae) twigs to treat malaria and its related symptoms. AIM OF STUDY: The main aim of this study was to evaluate the antiplasmodial [...] in P. capensis twigs. CONCLUSION: The study validates the ethnomedicinal use of P. capensis for malaria treatment. It demonstrated the potential of discovering novel antiplasmodial constituents that could