Cardiac alterations in human African trypanosomiasis (<em>T.b. gambiense</em>) with respect to the disease stage and antiparasitic treatment (Publications)
BACKGROUND: In Human African Trypanosomiasis, neurological symptoms dominate and cardiac involvement has been suggested. Because of increasing resistance to the available drugs for HAT, new compounds
Molecular epidemiology of pneumococci obtained from Gambian children aged 2-29 months with invasive pneumococcal disease during a trial of a 9-valent... (Publications)
BACKGROUND: The study describes the molecular epidemiology of Streptococcus pneumoniae causing invasive disease in Gambian children METHODS: One hundred and thirty-two S. pneumoniae isolates were reco
Comparative genomics of the anopheline glutathione s-transferase epsilon cluster (Publications)
Enzymes of the glutathione S-transferase (GST) family play critical roles in detoxification of xenobiotics across many taxa. While GSTs are ubiquitous both in animals and plants, the GST epsilon class
Improvements in access to malaria treatment in Tanzania following community, retail sector and health facility interventions - a user perspective (Publications)
BACKGROUND: The ACCESS programme aims at understanding and improving access to prompt and effective malaria treatment. Between 2004 and 2008 the programme implemented a social marketing campaign for i
Multi-host model-based identification of <em>Armillifer agkistrodontis</em> (Pentastomida), a new zoonotic parasite from China (Publications)
BACKGROUND: Pentastomiasis is a rare parasitic infection of humans. Pentastomids are dioecious obligate parasites requiring multiple hosts to complete their lifecycle. Despite their worm-like appearan
Low quality of routine microscopy for malaria at different levels of the health system in Dar es Salaam (Publications)
BACKGROUND: Laboratory capacity to confirm malaria cases in Tanzania is low and presumptive treatment of malaria is being practiced widely. In malaria endemic areas WHO now recommends systematic labor
Adherence to and acceptability of artemether-lumefantrine as first-line anti-malarial treatment: evidence from a rural community in Tanzania (Publications)
BACKGROUND: Controlled clinical trials have shown that a six-dose regimen of artemether-lumefantrine (AL) therapy for uncomplicated Plasmodium falciparum malaria results in cure rates > 95% with good
Interdependence of domestic malaria prevention measures and mosquito-human interactions in urban Dar es Salaam, Tanzania (Publications)
BACKGROUND: Successful malaria vector control depends on understanding behavioural interactions between mosquitoes and humans, which are highly setting-specific and may have characteristic features in
