Differences in affinity of monoclonal and naturally acquired polyclonal antibodies against <em>Plasmodium falciparum</em> merozoite antigens (Publications)
BACKGROUND: Malaria is a major global cause of deaths and a vaccine is urgently needed. RESULTS: We have employed the P. falciparum merozoite antigens MSP2-3D7/FC27 and AMA1, used them in ELISA, and coupled
<em>P. falciparum</em> and <em>P. vivax</em> orthologous coiled-coil candidates for a potential cross-protective vaccine (Publications)
Over the last four decades, significant efforts have been invested to develop vaccines against malaria. Although most efforts are focused on the development of P. falciparum vaccines, the current availability
Identification and deconvolution of cross-resistance signals from antimalarial compounds using multidrug-resistant <em>Plasmodium falciparum</em>... (Publications)
Plasmodium falciparum, the most deadly malaria agent, displays a wide variety of resistance mechanisms in the field. The ability of antimalarial compounds in development to overcome these must therefore
Evidence for limited activation of distinct CD4+ T cell subsets in response to the <em>Plasmodium falciparum </em>circumsporozoite protein in Papua... (Publications)
In this study, we have studied cellular and humoral responses of individuals naturally exposed to malaria in a highly endemic region of Papua New Guinea to the circumsporozoite protein of Plasmodium falciparum
Analysis of <em>Plasmodium falciparum</em> infections in a village community in Northern Nigeria: determination of msp2 genotypes and parasitespecific... (Publications)
PNG. The prevalence of IgG antibodies against the circumsporozoite protein (CSP), an indicator for malaria exposure, was over 85% in all age groups showing a high exposure of villagers to P. falciparum. OD
2-Octadecynoic acid as a dual life stage inhibitor of <em>Plasmodium</em> infections and plasmodial FAS-II enzymes (Publications)
The malaria parasite Plasmodium goes through two life stages in the human host, a non-symptomatic liver stage (LS) followed by a blood stage with all clinical manifestation of the disease. In this study
Global metabolic responses of NMRI mice to an experimental <em>Plasmodium berghei</em> infection (Publications)
metabolic profiling may provide a sensitive diagnostic tool of Plasmodium infection and the control of malaria more generally
Discovery of dual function acridones as a new antimalarial chemotype (Publications)
resistance, and both are undesirable in effective long-term strategies against multi-drug-resistant malaria. Haem remains an immutable and vulnerable target, because it is not parasite-encoded and its det
Histopathological changes in adult <em>Schistosoma japonicum</em> harbored in mice treated with a single dose of mefloquine (Publications)
New research has shown that mefloquine, an arylaminoalcohol used against malaria, is active against Schistosoma japonicum and Schistosoma mansoni in vivo. To enhance our understanding of the potential
A generic schema and data collection forms applicable to diverse entomological studies of mosquitoes (Publications)
BACKGROUND: Standardized schemas, databases, and public data repositories are needed for the studies of malaria vectors that encompass a remarkably diverse array of designs and rapidly generate large data volumes