Characterization of a serine hydrolase targeted by acyl-protein thioesterase inhibitors in <em>Toxoplasma gondii</em> (Publications)
palmitoylation contributes to key biological processes in Apicomplexa with the recent palmitome of the malaria parasite Plasmodium falciparum reporting over 400 substrates that are modified with palmitate by
<em>Plasmodium </em>Helical Interspersed Subtelomeric (PHIST) proteins, at the Center of Host Cell Remodeling (Publications)
PfEMP1, gametocytogenesis, changes in cell rigidity, and also cerebral and pregnancy-associated malaria. Thus, we conclude that PHIST proteins are central to host cell remodeling, but despite their obvious
Anti-trypanosomatid elemanolide sesquiterpene lactones from<em> Vernonia lasiopus </em>O. Hoffm (Publications)
Asteraceae family, has been extensively reported to be used ethno-medicinally as a treatment for malaria. Its crude extracts obtained with solvents of different polarity were screened in vitro for anti
Can school-based distribution be used to maintain coverage of long-lasting insecticide treated bed nets: evidence from a large scale programme in... (Publications)
achieved substantial gains in insecticide treated bednet coverage since 2005. The Tanzania National Malaria Control Programme identified school-based net distribution as one potential 'keep-up' strategy for
Time of exposure and assessment influence the mortality induced by insecticides against metabolic resistant mosquitoes (Publications)
BACKGROUND: Increasing metabolic resistance in malaria vector mosquitoes resulted in the development of insecticide-treated nets (ITNs) with active ingredients (AI) that target them. Bioassays that accurately
Quality of care for children with severe disease in the Democratic Republic of the Congo (Publications)
on a detailed list of disease symptoms observed, patients with severe febrile disease (including malaria), severe pneumonia, and severe dehydration were identified. For all three disease categories, treatments
Antiprotozoal dimeric naphthylisoquinolines, mbandakamines B3 and B4, and related 5,80'-coupled monomeric alkaloids, ikelacongolines A–D, from a... (Publications)
methods. The mbandakamines B3 (3) and B4 (4) displayed pronounced activities in vitro against the malaria parasite Plasmodium falciparum and the pathogen of African sleeping sickness, Trypanosoma brucei
Setting priorities for knowledge translation of Cochrane reviews for health equity: evidence for equity (Publications)
with high burdens of disease globally, were selected for the pilot: diabetes/obesity, HIV/AIDS, malaria, nutrition, and mental health/depression. For each topic area, a "stakeholder panel" was assembled
Ancistrobrevines E-J and related naphthylisoquinoline alkaloids from the West African liana <em>Ancistrocladus abbreviatus</em> with inhibitory... (Publications)
e compounds. Some of the alkaloids of A. abbreviatus exhibited promising activities against the malaria parasite Plasmodium falciparum and PANC-1 human pancreatic cancer cells.
Detection and monitoring of insecticide resistance mutations in <em>Anopheles gambiae</em>: individual vs pooled specimens (Publications)
Bioassays and molecular diagnostics are routinely used for the monitoring of malaria vector populations to support insecticide resistance management (IRM), guiding operational decisions on which insecticides