Occupational exposure to malaria, leishmaniasis and arbovirus vectors in endemic regions: a systematic review (Publications)
Vector-borne diseases, including dengue, leishmaniasis and malaria, may be more common among individuals whose occupations or behaviours bring them into frequent contact with these disease vectors outside [...] 16 online databases. The primary outcome was incidence or prevalence of dengue, leishmaniasis or malaria. The review excluded ecological and qualitative studies, abstracts only, letters, commentaries, reviews [...] Bite interventions for each risk group were assessed. 1170 articles were...
Severe coinfection of dengue and malaria: a case report (Publications)
substantial improvement in the diagnostic capacity. ABSTRACT: Here we report a case of dengue and malaria coinfection from the southeast region of Sudan, bordering Ethiopia and Eritrea. A 25-year-old male [...] vomiting, and muscle and joint pain. Laboratory investigations confirmed a coinfection of dengue and malaria, which is assumingly not uncommon in areas heavily syndemic with several diseases but it is severely [...] The case has fully recovered after the supportive care for dengue and...
Combined use of long-lasting insecticidal nets and <em>Bacillus thuringiensis israelensis</em> larviciding, a promising integrated approach against... (Publications)
BACKGROUND: The recent reduction in malaria burden in Côte d'Ivoire is largely attributable to the use of long-lasting insecticidal nets (LLINs). However, this progress is threatened by insecticide resistance [...] resistance and behavioral changes in Anopheles gambiae sensu lato (s.l.) populations and residual malaria transmission, and complementary tools are required. Thus, this study aimed to assess the efficacy [...] determined using a polymerase chain reaction technique. Plasmodium...
Reagent-free detection of <em>Plasmodium falciparum</em> malaria infections in field-collected mosquitoes using mid-infrared spectroscopy and machine... (Publications)
Field-derived metrics are critical for effective control of malaria, particularly in sub-Saharan Africa where the disease kills over half a million people yearly. One key metric is entomological inoculation [...] detect Plasmodium falciparum sporozoites in wild-caught Anopheles funestus, a major Afro-tropical malaria vector, without requiring any laboratory reagents. We collected 7178 female An. funestus from rural [...] detect P. falciparum in field-collected mosquitoes, with potential for...
Slow clearance of histidine-rich protein-2 in Gabonese with uncomplicated malaria (Publications)
Malaria rapid diagnostic tests (RDTs), which detect Plasmodium falciparum (Pf)-specific histidine-rich protein-2 (HRP2), have increasing importance for the diagnosis and control of malaria, especially [...] RDT-based assessment following a malaria treatment for weeks. A better understanding of the HRP2 clearance dynamics is critical for guiding the diagnosis of malaria when relying on RDTs. IMPORTANCE: Detecting [...] determine the long-term kinetic of HRP2-levels in peripheral blood after...
The impact of soil transmitted helminth on malaria clinical presentation and treatment outcome: a case control study among children in Bagamoyo... (Publications)
been documented between Plasmodium and STH. This study investigated the impact of STH on clinical malaria presentation and treatment outcome. METHODS: A matched case control study with a semi longitudinal [...] areas of Bagamoyo, coastal region of Tanzania. Cases were children with uncomplicated and severe malaria enrolled from the health facilities while controls were children with asymptomatic Plasmodium parasitemia [...] regression analysis there was a tendency for a protective effect of STH...
Embedded-deep-learning-based sample-to-answer device for on-site malaria diagnosis (Publications)
digital image transmission. This method can set a new paradigm for on-site malaria diagnosis. The miLab™ algorithm for malaria detection achieved a total accuracy of 98.86% for infected red blood cell (RBC) [...] Improvements in digital microscopy are critical for the development of a malaria diagnosis method that is accurate at the cellular level and exhibits satisfactory clinical performance. Digital microscopy [...] 92.21%. Based on these results, miLab™ can become a reliable and efficient...
Field evaluation of a volatile pyrethroid spatial repellent and etofenprox treated clothing for outdoor protection against forest malaria vectors in... (Publications)
Cambodia's goal to eliminate malaria by 2025 is challenged by persistent transmission in forest and forest fringe areas, where people are exposed to Anopheles mosquito bites during the day and night. Volatile [...] the potential to reduce outdoor and daytime Anopheles biting, offering valuable contributions to malaria elimination efforts in Cambodia and the Greater Mekong Subregion, contingent upon achieving effective
Identification of potent and reversible piperidine carboxamides that are species-selective orally active proteasome inhibitors to treat malaria (Publications)
Malaria remains a global health concern as drug resistance threatens treatment programs. We identified a piperidine carboxamide (SW042) with anti-malarial activity by phenotypic screening. Selection of [...] Pf_proteasome β5 active-site (Pfβ5). A potent analog (SW584) showed efficacy in a mouse model of human malaria after oral dosing. SW584 had a low propensity to generate resistance (minimum inoculum for resistance
