Imaging of <em>Plasmodium</em> liver stages to drive next-generation antimalarial drug discovery (Publications)
Most malaria drug development focuses on parasite stages detected in red blood cells, even though to achieve eradication, next-generation drugs active against both erythrocytic and exo-erythrocytic fo
Development and validation of the Kilifi stigma scale for epilepsy in Kenya (Publications)
The aim of this study was to develop and validate a tool to measure perceived stigma among people with epilepsy (PWE) in Kilifi, Kenya. We reviewed existing scales that measured stigma, particularly o
Design, synthesis and evaluation of novel uracil amino acid conjugates for the inhibition of <em>Trypanosoma cruzi </em>dUTPase (Publications)
Potential inhibitors of the Trypanosoma cruzi dUTP nucleotidohydrolase were docked into the enzyme using the program FlexX. Compounds that docked selectively were then selected and synthesized using s
Traffic, susceptibility, and childhood asthma (Publications)
Results from studies of traffic and childhood asthma have been inconsistent, but there has been little systematic evaluation of susceptible subgroups. In this study, we examined the relationship of lo
Systems to support health technology assessment (HTA) in member states of the European union with limited institutionalization of HTA (Publications)
OBJECTIVES: The aim of this study was to support health technology assessment (HTA) capacity building in Member States of the European Union with limited experience or without institutionalized HTA. T
Bis(oxyphenylene)benzimidazoles: a novel class of anti-<em>Plasmodium falciparum</em> agents (Publications)
A small library of 26 2,2'-[alkane-alpha,omega-diylbis(oxyphenylene)]bis-1H-benzimidazoles has been prepared and evaluated against Giardia intestinalis, Entamoeba histolytica, Trypanosoma brucei rhode
Antiparasitic agents: new drugs on the horizon (Publications)
The need for new drugs against tropical parasites such as Plasmodium falciparum and Trypanosoma brucei is persistent since problems with resistance and toxicity are jeopardizing the currently availabl