Discrepancy in plasma melarsoprol concentrations between HPLC and bioassay methods in patients with <em>T. gambiense</em> sleeping sickness indicates... (Publications)
OBJECTIVE: With the use of a specific high-performance liquid chromatography (HPLC) method and a bioassay which determines trypanocidal activity, concentrations of melarsoprol were assessed in plasma,
Prevalence of airflow obstruction in smokers and never smokers in Switzerland (Publications)
We aimed to measure age-specific prevalence of airflow obstruction (AO) in Switzerland in smokers and never smokers using pulmonary function tests and respiratory symptoms from 6126 subjects participa
Alternative application of melarsoprol for treatment of <em>T.b. gambiense</em> sleeping sickness: preliminary results (Publications)
The protocols for treatment of human African trypanosomiasis (sleeping sickness) with the organoarsenical drug melarsoprol are based on empirical observations. Therapy is often accompanied by serious
Long-term decline in lung function, utilisation of care and quality of life in modified GOLD stage 1 COPD (Publications)
BACKGROUND: Little is known about the long-term outcomes of individuals with mild chronic obstructive pulmonary disease (COPD) as defined by the Global Initiative for Chronic Obstructive Lung Disease
Synthesis, structure-activity relationship, and mode-of-action studies of antimalarial reversed chloroquine compounds (Publications)
We have previously shown that a "reversed chloroquine (RCQ)" molecule, composed of a chloroquine-like moiety and a resistance reversal-like moiety, can overcome chloroquine resistance in P. falciparum
Shoot growth of mature Fagus sylvatica and Picea abies in relation to ozone (Publications)
Epidemiological analysis of sequential growth data may be a tool in assessing ozone sensitivity of mature trees. Annual shoot growth of mature Fagus sylvatica in 83 Swiss permanent forest observation
Jozimine A2: the first dimeric dioncophyllaceae-type naphthylisoquinoline alkaloid, with three chiral axes and high antiplasmodial activity (Publications)
A new dimeric naphthylisoquinoline alkaloid, jozimine A(2) (2), was isolated from the root bark of an Ancistrocladus species from the Democratic Republic of Congo. Its absolute stereostructure was det
Measuring and validating physical activity and sedentary behavior comparing a parental questionnaire to accelerometer data and diaries (Publications)
Accurately measuring children's physical activity and their sedentary behavior is challenging. The present study compared 189 parental responses to a questionnaire surveying physical activity and sede
