Building-related health impacts in European and Chinese cities: a scalable assessment method (Publications)
impacts, both positive and negative, on public health. Our main objective was to develop a generic open impact model to estimate health impacts of emissions due to heat and power consumption of buildings [...] and large impacts on emissions. However, the life cycle impacts of different fuels is somewhat an open question. CONCLUSIONS: In conclusion, we were able to develop a practical model for city-level assessments
Country modelling to support National Malaria Control Programs - High Burden to High Impact (Projects)
https://www.swisstph.ch/de/projects/project-detail/project/country-modelling-to-support-national-malaria-control-programs-high-burden-to-high-impact
of malaria-related interventions. Our work is based on the OpenMalaria modelling platform developed by the Swiss TPH and collaborators. OpenMalaria has been developed as a decision-making support tool
Modelling support to decision-making for malaria control in Benin (Projects)
https://www.swisstph.ch/de/projects/project-detail/project/modelling-support-to-decision-making-for-malaria-control-in-benin
to gather a deeper understanding of the past malaria burden and control efforts. We then calibrate OpenMalaria , the malaria transmission simulation platform developed in-house, to quantify the transmission [...] malaria chemoprevention to children until 10 in few regions or until 5 in a larger area. We use again OpenMalaria to project the impact of the interventions on prevalence, incidence and severe cases. We provide
Characteristics of persistent hotspots of <em>Schistosoma mansoni</em> in western Côte d'Ivoire (Publications)
infected children, was 123.8 EPG in PHS and 18.7 EPG in the other two schools. Children bathing in open freshwater bodies were at higher odds of S. mansoni infection (odds ratio: 4.5, 95% confidence interval: [...] forskalii, Bu. globosus and Bu. truncatus). CONCLUSION: Children in PHS schools bathed more frequently in open freshwater bodies, and hence, they are more exposed to Schistosoma transmission. Our findings call
Assessing the Potential Health Impact of Omicron (News)
https://www.swisstph.ch/de/news/assessing-the-potential-health-impact-of-omicron
Modelling unit has been setting up an open-access transmission model for COVID-19 since the beginning of the pandemic, building on its experience in malaria modelling. “Our OpenCOVID transmission model provides
Efficacy of 10-day melarsoprol schedule 2 years after treatment for late-stage gambiense sleeping sickness (Publications)
treatment for late-stage human African trypanosomiasis. This alternative schedule was assessed in an open, randomised clinical equivalence trial of 500 patients in Angola. 24 h after treatment, all patients
A nucleoside transporter from <em>Trypanosoma brucei</em> involved in drug resistance (Publications)
harbor a defective TbAT1 variant. The molecular identification of the entry route of trypanocides opens the way to approaches for diagnosis and treatment of drug-resistant sleeping sickness
Efficacy of 10-day melarsoprol schedule 2 years after treatment for late-stage gambiense sleeping sickness (Publications)
treatment for late-stage human African trypanosomiasis. This alternative schedule was assessed in an open, randomised clinical equivalence trial of 500 patients in Angola. 24 h after treatment, all patients
A nucleoside transporter from <em>Trypanosoma brucei</em> involved in drug resistance (Publications)
harbor a defective TbAT1 variant. The molecular identification of the entry route of trypanocides opens the way to approaches for diagnosis and treatment of drug-resistant sleeping sickness
Ensuring transmission through dynamic host environments: host-pathogen interactions in <em>Plasmodium </em>sexual development (Publications)
sexual development, especially host cell remodeling and sequestration in the bone marrow, highlight open questions regarding parasite homing to the tissue, transmigration across the vascular endothelium
