Pharmacokinetics, <em>Trypanosoma brucei gambiense</em> efficacy and time of drug action of DB829, a preclinical candidate for treatment of second... (Publications)
Human African trypanosomiasis (HAT, sleeping sickness), a neglected tropical disease endemic to sub-Saharan Africa, is caused by the parasites Trypanosoma brucei (T. b.) gambiense and T. b. rhodesiens
Economics of brucellosis impact and control in low-income countries (Publications)
Most data and evidence on the economic burden of brucellosis and the benefits of its control are from high-income and middle-income countries. However, the burden of brucellosis is greatest in low-inc
Synthesis and in vitro and in vivo evaluation of antimalarial polyamines (Publications)
We recently reported that 1,14-diphenylacetamide derivatives of spermine exhibit potent nM in vitro growth inhibition properties of Plasmodium falciparum. In an effort to expand the structure-activity
A pilot study characterizing real time exposures to particulate matter and carbon monoxide from cookstove related woodsmoke in rural Peru (Publications)
Nearly half of the world's population is exposed to household air pollution (HAP) due to long hours spent in close proximity to unvented cooking fires. We aimed to use PM2.5 and CO measurements to cha
UV-triggered affinity-capture identifies interactions between the <em>Plasmodium falciparum</em> multidrug resistance protein 1 (PfMDR1) and... (Publications)
A representative of a new class of potent antimalarials with an unknown mode of action was recently described. To identify the molecular target of this class of antimalarials, we employed a photo-reac
Synthesis and antiprotozoal activities of benzyl phenyl ether diamidine derivatives (Publications)
Sixty-two cationic benzyl phenyl ether derivatives (36 amidines and 26 prodrugs) were prepared and assayed for activities in vitro and in vivo against Trypanosoma brucei rhodesiense (STIB900), and in
