Investigating sulfoxide-to-sulfone conversion as a prodrug strategy for a phosphatidylinositol 4-kinas inhibitor in a humanized mouse model of malaria (Publications)
its corresponding sulfone metabolite, were evaluated in the NOD-scid IL2Rgamma(null) (NSG) murine malaria disease model of Plasmodium falciparum infection. We hypothesized that the sulfoxide would serve [...] dosed, thereby demonstrating that the sulfoxide served as an effective prodrug for the treatment of malaria.
Provision of a Scoping Study for a Strategic Environmental Assessment (SEA) on behalf of Target Malaria (Projects)
https://www.swisstph.ch/de/projects/project-detail/project/provision-of-a-scoping-study-for-a-strategic-environmental-assessment-sea-on-behalf-of-target-malaria
Genetically modified mosquitoes represent great potential for malaria control. Any future application of gene drive mosquitoes for malaria control will require many elements, including policy action, [...] to suppress populations of malaria vector mosquitoes. The assessments main objectives are to: (i) raise awareness amongst policy makers of genetic control tools for malaria using gene drives (ii) develop [...] gene drive (the action) and subsequent reduction of malaria (the desired effect)...
Spatio-temporal modelling to assess the impact of climate change on the burden of malaria and to support early warning systems (Projects)
https://www.swisstph.ch/de/projects/project-detail/project/spatio-temporal-modelling-to-assess-the-impact-of-climate-change-on-the-burden-of-malaria-and-to-support-early-warning-systems
climate variability, land use, malaria vector control coverage and socio-economic factors to changes in malaria incidence and mortality; (ii) develop stochastic metapopulation malaria transmission models which [...] statistical models to forecast malaria; (iv) evaluate the effects of environmental vector-control with microbial larvicides on the burden of malaria; and (v) project future malaria burden based on scenarios [...] changes, malaria interventions and socioeconomic effects, which are...
BACKUP Health Cameroon - Improving Access to Malaria Care and Services for Children Under Five: Pilot Project (Projects)
https://www.swisstph.ch/de/projects/project-detail/project/backup-health-cameroon-improving-access-to-malaria-care-and-services-for-children-under-five-pilot-project
approximately $101 million will go to malaria treatment and control programs. These funds are expected to be absorbed through the end of 2023. The National Malaria Control Program (PNLP) is working towards [...] groups of activities: Estimation of the costs of malaria treatment services and care: The aim is to propose three cost models for the management of all malaria care: "basic", "standard" and "comprehensive" [...] goal is to customize openIMIS to meet the needs of malaria care management....
Malawi Malaria Indicator Survey Quality Assurance Services (Projects)
https://www.swisstph.ch/de/projects/project-detail/project/malawi-malaria-indicator-survey-quality-assurance-services
Malaria indicator surveys are an important source of data on disease burden (parasite prevalence, fever prevalence, etc), and coverage of malaria prevention and case management interventions, particularly [...] decisions. The objective of this mandate of Global Fund was to assess the extent to which the Malawi malaria indicator survey 2021 activities were planned, coordinated, and executed according to the standard
Core Malaria Modelling (Projects)
https://www.swisstph.ch/de/projects/project-detail/project/core-malaria-modelling
and use of an individual-based model of malaria transmission dynamics known as OpenMalaria. This model is an open-source tool for simulating the dynamics of malaria transmission and epidemiology, and the [...] and economic outcomes. The opensource code and details of our model OpenMalaria can be found here . The model can simulate malaria in village or district size human populations, and has been used to address [...] TPH, our OpenMalaria model is used by a wide range of modellers worldwide....
Towards Elimination of Malaria in Tanzania (Projects)
https://www.swisstph.ch/de/projects/project-detail/project/towards-elimination-of-malaria-in-tanzania
Malaria and poverty entertain a close relationship through historical times. Past studies have abundantly documented the benefits of malaria control on economic development and human well-being, and as [...] of malaria across the country declined, the heterogeneity in transmission greatly increased. At present, some areas in Tanzania remain with a very high transmission and hence with a high malaria burden [...] and risk stratification followed by decentralized malaria control planning has...
Experience capitalisation of Biovision’s environmental-friendly Malaria and African animal trypanosomiasis control projects from 2005-2020 for greater... (Projects)
https://www.swisstph.ch/de/projects/project-detail/project/experience-capitalisation-of-biovisions-environmental-friendly-malaria-and-african-animal-trypanosomiasis-control-projects-from-2005-2020-for-greater-impact
be an assessment of Biovision’s engagement in Malaria and AAT control. Two major outputs shall be developed based on this review: a) an overview of Malaria and tsetse fly control activities supported through [...] of vector-borne human, animal and plant diseases. The current mandate focuses on programmes for Malaria and AAT control with a flagship character that had been implemented by Biovision and their strong [...] These will address the following four key topics: a) uptake, ownership and...
Papua New Guinea National Malaria Control Programme Evaluation and Operational Research 2021 to 2023 (Projects)
https://www.swisstph.ch/de/projects/project-detail/project/papua-new-guinea-national-malaria-control-programme-evaluation-and-operational-research-2021-to-2023
exhibits a complex malaria epidemiology with marked heterogeneity in malaria transmission. With financial support from the Global Fund to Fight AIDS, Tuberculosis and Malaria, the National Malaria Control Program [...] across PNG to assess quality of malaria case management. Activity 2: a national Malaria Indicator Survey (MIS) to track progress in malaria intervention coverage and malaria prevalence on national and regional [...] changing malaria epidemiology in PNG (including aspects related...
