Insecticide-treated nets for preventing malaria (Publications)
severe malaria episodes. Insecticide-treated nets have since become a core intervention for malaria control and have contributed greatly to the dramatic decline in disease incidence and malaria-related [...] to estimate the impact of ITNs on malaria transmission today. OBJECTIVES: The primary objective of this review was to assess the impact of ITNs on mortality and malaria morbidity, incorporating any evidence [...] falciparum malaria by 17% compared to no nets (RR 0.83, 95% CI 0.71 to 0.98; 6...
Diagnostic performance of conventional and ultrasensitive rapid diagnostic tests for malaria in febrile outpatients in Tanzania (Publications)
Background: A novel ultra-sensitive malaria RDT (us-RDT) has been developed for improved active P.falciparum case detection. The utility of this us-RDT in clinical diagnosis and fever management has not [...] infections. Conclusion: There is neither gain nor risk to apply us-RDT rather than co-RDT for clinical malaria diagnosis. In febrile patients, only a small proportion of infections are characterized by parasite
Spatial-temporal heterogeneity in malaria receptivity is best estimated by vector biting rates in areas nearing elimination (Publications)
when vector control can be withdrawn after malaria is eliminated depend on the receptivity or potential of an area to support vector populations. To guide malaria control and elimination programmes, the potential [...] estimate malaria receptivity and transmission were compared within and among geographically localised villages of active transmission in the Western Province of the Solomon Islands. RESULTS: Malaria transmission [...] inoculation and parity rates could not be measured with the...
Inter-sectoral approaches for the prevention and control of malaria among the mobile and migrant populations: a scoping review (Publications)
knowledge about malaria, initiation and promotion of bed nets utilization, increased access to diagnosis and treatment in a surveillance context and contributed towards a reduction in malaria transmission [...] with correct knowledge about malaria transmission (70%, 95% CI 57-83%). Interventions targeting the use of bed nets utilization were two times more likely to reduce malaria incidence amongst the targeted [...] BACKGROUND: Malaria cases among mobile and migrant populations (MMPs) represent...
Nationwide school malaria parasitaemia survey in public primary schools, the United Republic of Tanzania (Publications)
school, malaria survey was implemented to assess the risk factors of malaria prevalence and bed net use among primary school children in mainland Tanzania. This allowed the mapping of malaria prevalence [...] for malaria infection and for bed net use while adjusting for school effect. RESULTS: In total, 49,113 children were interviewed and tested for malaria infection. The overall prevalence of malaria was [...] prevalence at council level and assessment of malaria risk factors among school...
The origins of malaria artemisinin resistance defined by a genetic and transcriptomic background (Publications)
The predisposition of parasites acquiring artemisinin resistance still remains unclear beyond the mutations in Pfk13 gene and modulation of the unfolded protein response pathway. To explore the chain
How Gold Mining Affects the Spread of Malaria (News)
https://www.swisstph.ch/de/news/news-detail-1/news/how-gold-mining-affects-the-spread-of-malaria
using black market medicines further increase the risk of malaria transmission. “The international gold price has been the best predictor of malaria rates in Guyana,” said Pablo De Salazar from Swiss TPH [...] higher risk of malaria transmission. A recently published case study by Swiss TPH and partners analysed how Brazil’s 2023 crackdown on illegal gold mining in Yanomami lands triggered a malaria outbreak in [...] the rise in malaria cases in Guyana, demonstrating how the displacement of...
Mathematical models to define new malaria immunotherapies and interventions to meet public health needs (Projects)
https://www.swisstph.ch/de/projects/project-detail/project/mathematical-models-to-define-new-malaria-immunotherapies-and-interventions-to-meet-public-health-needs
progress in fighting malaria, there remains a need for new antimalarial interventions to protect children and other vulnerable populations who experience the highest burden of malaria. Developing new in [...] from academia, product development partners, and representatives from malaria-endemic countries. Our focus is on next-generation malaria vaccines, monoclonal antibodies, and new chemoprevention antimalarials
