Targeting <em>Plasmodium </em>plasmepsin V: hitting two birds with one stone (Publications)
A recent report by Jennison et al. reveals an important role for plasmepsin V (PMV), an aspartyl protease, in the development of malaria transmission stages. The authors showed that PMV activity is cr
Stochastic protein alkylation by antimalarial peroxides (Publications)
Antimalarial peroxides such as the phytochemical artemisinin or the synthetic ozonides arterolane and artefenomel undergo reductive cleavage of the pharmacophoric peroxide bond by ferrous heme, releas
Dispersal of <em>Mycobacterium tuberculosis </em>driven by historical European trade in the South Pacific (Publications)
Mycobacterium tuberculosis (Mtb) is a globally distributed bacterial pathogen whose population structure has largely been shaped by the activities of its obligate human host. Oceania was the last majo
Structure, biosynthesis, and bioactivity of photoditritide from <em>Photorhabdus temperata</em> Meg1 (Publications)
A new cyclic peptide photoditritide (1), containing two rare amino acid d-homoarginine residues, was isolated from Photorhabdus temperata Meg1 after the nonribosomal peptide synthetase encoding gene p
How urban characteristics affect vulnerability to heat and cold: a multi-country analysis (Publications)
BACKGROUND: The health burden associated with temperature is expected to increase due to a warming climate. Populations living in cities are likely to be particularly at risk, but the role of urban ch
Mosquito repellents for malaria prevention (Review) (Publications)
BACKGROUND: Malaria is an important cause of illness and death across endemic regions. Considerable success against malaria has been achieved within the past decade mainly through long-lasting insecti
Impedance-based microfluidic assay for automated antischistosomal drug screening (Publications)
Schistosomiasis is a neglected tropical disease, caused by parasitic worms, which affects almost 200 million people worldwide. For over 40 years, chemotherapeutic treatment has relied on the administr
Elusive cranial lesions severely afflicting young endangered Patagonian huemul deer (Publications)
OBJECTIVES: Most subpopulations of endangered huemul deer (Hippocamelus bisulcus) fail to recover, frequently due to osteopathology. Equivalent pathology was detected only postmortem in an additional
The overlap between miscarriage and extreme preterm birth in a limited-resource setting on the Thailand-Myanmar border: a population cohort study (Publications)
Background : No universal demarcation of gestational age distinguishes miscarriage and stillbirth or extreme preterm birth (exPTB). This study provides a synopsis of outcome between 22 to /=22 weeks.
