PfSPZ Vaccine induces focused humoral immune response in HIV positive and negative Tanzanian adults (Publications)
stage malaria vaccine candidate based on whole, radiation-attenuated Plasmodium falciparum (Pf) sporozoites (SPZ), has proven safe and effective in mediating sterile protection from malaria in malaria-naïve [...] underexplored, target for vaccine-induced antibodies in malaria pre-exposed volunteers. FUNDING: This work was supported by the Equatorial Guinea Malaria Vaccine Initiative (EGMVI), the Clinical Trial Platform [...] , we profiled IgG and IgM responses to PfSPZ Vaccine and subsequent...
On-target, dual aminopeptidase inhibition provides cross-species antimalarial activity (Publications)
known as MMV1557817, and show that it targets multiple stages of the malaria parasite lifecycle, is active in a preliminary mouse malaria model, and has a novel mechanism of action. Excitingly, resistance [...] To combat the global burden of malaria, development of new drugs to replace or complement current therapies is urgently required. Here, we show that the compound MMV1557817 is a selective, nanomolar inhibitor [...] digestion in asexual parasites. MMV1557817 can kill sexual-stage P....
The relative roles of ANC and EPI in the continuous distribution of LLINs: a qualitative study in four countries (Publications)
through EPI because of a) stronger linkages and involvement between malaria and reproductive health programmes, as compared to malaria and EPI, and b) more complete programme monitoring for ANC-based d [...] Background: The continuous distribution of long-lasting insecticidal nets (LLINs) for malaria prevention, through the antenatal care (ANC) and the Expanded Programme on Immunizations (EPI), is recommended [...] sub-national, and facility-level health staff, and were selected to capture a...
R. Geigy-Preis 2020 geht an Tobias Schindler (News)
https://www.swisstph.ch/de/news/news-detail-1/news/r-geigy-preis-2020-geht-an-tobias-schindler
war der Aufbau einer Testumgebung, die eine kontrollierte Malaria-Infektion zuliess. Den Probandinnen und Probanden wurden infektiöse Malaria-Erreger, sogenannte Sporozoiten, injiziert. Und sie wurden [...] Selbstverständlichkeit. Noch immer werden Patientinnen und Patienten mit Fieber routinemässig gegen Malaria behandelt. Tobias Schindler, Postdoktorand am Swiss TPH, entwickelte zusammen mit Partnern vom Ifakara [...] Ifakara Health Institute (IHI) eine molekulare Diagnostik-Plattform für den...
Bite Interruption Towards Elimination (Projects)
https://www.swisstph.ch/de/projects/project-detail/project/bite-interruption-towards-elimination
progress in reducing malaria transmission in the Greater Mekong Subregion (GMS). However progress has stalled with reports of increase in the number of cases, multi-drug resistant malaria and pyrethroid-resistant [...] mobile and migrant populations, including forest-goers and forest rangers. Many of the dominant malaria vectors in the region feed and rest outdoors yet there is limited available protection against mosquito [...] populations. To address these pressing challenges, the University...
Phase 1 study in Tanzania to evaluate the safety and immunogenicity of BSPZV1 - a vaccine against Plasmodium falciparum sporozoite (PfSPZ) (Projects)
https://www.swisstph.ch/de/projects/project-detail/project/phase-1-study-in-tanzania-to-evaluate-the-safety-and-immunogenicity-of-bspzv1-a-vaccine-against-plasmodium-falciparum-sporozoite-pfspz
Vaccine) in Tanzanian adults Malaria is one of the most severe diseases in tropical countries. During the last decade, great effort has led to success in controlling malaria transmission, morbidity and [...] and mortality. Nevertheless, still around 660 000 people die due to malaria infection per year. For further reduction and, ideally, to gain elimination of this of this burden, a vaccine is crucial. Since [...] well as induction of immune response. Afterwards, protective efficacy is tested by...
Defining the next generation of <em>Plasmodium vivax</em> diagnostic tests for control and elimination: target product profiles (Publications)
prevalence of malaria has decreased over the past fifteen years, but similar gains have not been realized against Plasmodium vivax because this species is less responsive to conventional malaria control i [...] interventions aimed principally at P. falciparum. Approximately half of all malaria cases outside of Africa are caused by P. vivax. This species places dormant forms in human liver that cause repeated clinical [...] clinical attacks without involving another mosquito bite. The diagnosis...
Pre-referral rectal artesunate: no cure for unhealthy systems (Publications)
rectal artesunate in settings where malaria mortality remains high. Without improving the entire continuum of care, children will continue to die from severe malaria and promising interventions will fail [...] Pre-referral rectal artesunate suppositories can save the lives of children with severe malaria if patients receive adequate post-referral care. A multi-country randomised controlled trial reporting on [...] In October, 2022, we reported on the findings of the Community Access to Rectal...
Pre-referral rectal artesunate: no cure for unhealthy systems (Publications)
rectal artesunate in settings where malaria mortality remains high. Without improving the entire continuum of care, children will continue to die from severe malaria and promising interventions will fail [...] Pre-referral rectal artesunate suppositories can save the lives of children with severe malaria if patients receive adequate post-referral care. A multi-country randomised controlled trial reporting on [...] In October, 2022, we reported on the findings of the Community Access to Rectal...
Defining the next generation of <em>Plasmodium vivax</em> diagnostic tests for control and elimination: target product profiles (Publications)
prevalence of malaria has decreased over the past fifteen years, but similar gains have not been realized against Plasmodium vivax because this species is less responsive to conventional malaria control i [...] interventions aimed principally at P. falciparum. Approximately half of all malaria cases outside of Africa are caused by P. vivax. This species places dormant forms in human liver that cause repeated clinical [...] clinical attacks without involving another mosquito bite. The diagnosis...
