Identification and validation of a gene causing cross-resistance between insecticide classes in <em>Anopheles gambiae</em> from Ghana (Publications)
reductions in malaria incidence in sub-Saharan Africa. Sustaining these reductions will rely upon insecticides to control the mosquito malaria vectors. We report that in the primary African malaria vector, Anopheles [...] simultaneously reduces the efficacy of two of the four classes of insecticide routinely used for malaria control. The gene-expression profile of a highly DDT-resistant population of A. gambiae s.s. from
Rapid diagnostic tests for non-malarial febrile illness in the tropics (Publications)
of rapid diagnostic tests (RDTs) for malaria has highlighted the decreasing proportion of malaria-attributable illness in endemic areas. Unfortunately, once malaria is excluded, there are few accessible [...] pressing need for sensitive pathogen-detection-based RDTs, as have been successfully developed for malaria and dengue. Ultimately, integration of RDTs into a validated syndromic approach to tropical fevers
Identification and validation of a gene causing cross-resistance between insecticide classes in <em>Anopheles gambiae</em> from Ghana (Publications)
reductions in malaria incidence in sub-Saharan Africa. Sustaining these reductions will rely upon insecticides to control the mosquito malaria vectors. We report that in the primary African malaria vector, Anopheles [...] simultaneously reduces the efficacy of two of the four classes of insecticide routinely used for malaria control. The gene-expression profile of a highly DDT-resistant population of A. gambiae s.s. from
Rapid diagnostic tests for non-malarial febrile illness in the tropics (Publications)
of rapid diagnostic tests (RDTs) for malaria has highlighted the decreasing proportion of malaria-attributable illness in endemic areas. Unfortunately, once malaria is excluded, there are few accessible [...] pressing need for sensitive pathogen-detection-based RDTs, as have been successfully developed for malaria and dengue. Ultimately, integration of RDTs into a validated syndromic approach to tropical fevers
Immunoglobulin G subclass-specific responses against <em>Plasmodium falciparum</em> merozoite antigens are associated with control of parasitemia and... (Publications)
merozoite antigens play a role in protection from malaria, although the precise targets and mechanisms mediating immunity remain unclear. Different malaria antigens induce distinct immunoglobulin G (IgG) [...] (IgG) subclass responses, but the importance of different responses in protective immunity from malaria is not known and the factors determining subclass responses in vivo are poorly understood. We examined [...] AMA-1-specific IgG3 and MSP1-19-specific IgG1 were strongly predictive of a...
Aetiology of fever in returning travelers and migrants: a systematic review and meta-analysis (Publications)
openia and hyperbilirubinemia were respectively 5-14, 3-11 and 5-7 times more likely in malaria than non-malaria patients. High variability of results between studies reflects heterogeneity in study design [...] investigations performed, and diseases included. CONCLUSION: Malaria accounted for one fifth of febrile cases, highlighting the importance of rapid malaria testing in febrile returning travelers, followed by other [...] met criteria for data extraction. Tropical infections accounted for...
The activities of current antimalarial drugs on the life cycle stages of <em>Plasmodium</em>: a comparative study with human and rodent parasites (Publications)
to alleviate symptoms of malaria in the blood stage. To overcome this critical gap, we developed assays to measure activity of antimalarials against all life stages of malaria parasites, using a diverse [...] BACKGROUND: Malaria remains a disease of devastating global impact, killing more than 800,000 people every year-the vast majority being children under the age of 5. While effective therapies are available [...] available, if malaria is to be eradicated a broader range of small molecule...
Withholding antimalarials in febrile children who have a negative result for a rapid diagnostic test (Publications)
admitted to the hospital subsequently, all with negative results for malaria tests upon admission. Two of them died, of causes other than malaria. Conclusions. Not giving antimalarial drugs in febrile children [...] Background. The availability of a rapid diagnostic test for malaria (RDTm) allows accurate diagnosis at all levels of health facilities. The objective of the present study was to evaluate the safety of [...] prospective 2-arm longitudinal study in areas of Tanzania that are...
Aetiology of fever in returning travelers and migrants: a systematic review and meta-analysis (Publications)
openia and hyperbilirubinemia were respectively 5-14, 3-11 and 5-7 times more likely in malaria than non-malaria patients. High variability of results between studies reflects heterogeneity in study design [...] investigations performed, and diseases included. CONCLUSION: Malaria accounted for one fifth of febrile cases, highlighting the importance of rapid malaria testing in febrile returning travelers, followed by other [...] met criteria for data extraction. Tropical infections accounted for...
The activities of current antimalarial drugs on the life cycle stages of <em>Plasmodium</em>: a comparative study with human and rodent parasites (Publications)
to alleviate symptoms of malaria in the blood stage. To overcome this critical gap, we developed assays to measure activity of antimalarials against all life stages of malaria parasites, using a diverse [...] BACKGROUND: Malaria remains a disease of devastating global impact, killing more than 800,000 people every year-the vast majority being children under the age of 5. While effective therapies are available [...] available, if malaria is to be eradicated a broader range of small molecule...
