Amino acid dimorphism and parasite immune evasion: cellular immune responses to a promiscuous epitope of<em> Plasmodium falciparum</em> merozoite... (Publications)
suitability as component of a multi-epitope malaria vaccine. We have analyzed the CD4 T cell responses in a group of human volunteers immunized with a synthetic malaria peptide vaccine containing a single MSP-143-53 [...] Like most other surface-exposed antigens of Plasmodium falciparum, the leading malaria vaccine candidate merozoite surface protein (MSP)-1 contains a large number of dimorphic amino acid positions. This [...] diversity is presumed to be associated with parasite immune evasion...
Situation épidémiologique avant la mise en eau du barrage hydroagricole de cinq villages de Bouaké, centre Côte d'Ivoire (Publications)
intermediate host snails of parasitic diseases related to water, and to assess the prevalence of malaria, schistosomiasis and soil-transmitted helminthiasis before dam construction. Mosquitoes were caught [...] in water bodies, and microscopic analyses of blood, stool and urine samples were carried out. Two malaria vector species were identified: Anopheles gambiae and Anopheles funestus. The average infective rate [...] species of were found: Plasmodium falciparum (predominant species),...
Amino acid dimorphism and parasite immune evasion: cellular immune responses to a promiscuous epitope of<em> Plasmodium falciparum</em> merozoite... (Publications)
suitability as component of a multi-epitope malaria vaccine. We have analyzed the CD4 T cell responses in a group of human volunteers immunized with a synthetic malaria peptide vaccine containing a single MSP-143-53 [...] Like most other surface-exposed antigens of Plasmodium falciparum, the leading malaria vaccine candidate merozoite surface protein (MSP)-1 contains a large number of dimorphic amino acid positions. This [...] diversity is presumed to be associated with parasite immune evasion...
Situation épidémiologique avant la mise en eau du barrage hydroagricole de cinq villages de Bouaké, centre Côte d'Ivoire (Publications)
intermediate host snails of parasitic diseases related to water, and to assess the prevalence of malaria, schistosomiasis and soil-transmitted helminthiasis before dam construction. Mosquitoes were caught [...] in water bodies, and microscopic analyses of blood, stool and urine samples were carried out. Two malaria vector species were identified: Anopheles gambiae and Anopheles funestus. The average infective rate [...] species of were found: Plasmodium falciparum (predominant species),...
Following in Soper's footsteps: northeast Brazil 63 years after eradication of <em>Anopheles gambiae</em> (Publications)
years ago was a new and horrifying experience. This African mosquito is an exceptionally effective malaria vector because it is well adapted to feeding upon people and to exploiting aquatic habitats associated [...] with our daily activities. Anopheles gambiae sensu lato probably accounts for most of the world's malaria deaths and socioeconomic burden. Fortunately, the Brazilian experience had a happy ending. The prospect [...] aegypti elimination, the Rockefeller Foundation and Brazilian...
Resistance to Artemisinin Combination Therapies (ACTs): do not forget the partner drug! (Publications)
Artemisinin-based combination therapies (ACTs) have become the mainstay for malaria treatment in almost all malaria endemic settings. Artemisinin derivatives are highly potent and fast acting antimalarials; [...] regimen. When introduced, ACTs were highly efficacious and contributed to the steep decrease of malaria over the last decades. However, parasites with decreased susceptibility to artemisinins have emerged [...] ce and potential solutions to extend the useful therapeutic lifespan of the...
SNSF Professorship Awarded to Melissa Penny (News)
https://www.swisstph.ch/de/news/news-detail-1/news/snsf-professorship-awarded-to-melissa-penny
medicines and vaccines more efficient, ensuring innovation and tailoring of these interventions towards malaria and disease elimination.” Melissa Penny has been a project leader at Swiss TPH since 2013, focusing [...] focusing on developing mathematical models that provide quantitative evidence to support malaria control and elimination decisions. She recently led a multi-institute collaboration to provide evidence to the [...] Organization (WHO) and other institutions on the public health...
Clinical Immunology (Page)
https://www.swisstph.ch/de/about/mpi/clinical-immunology
First-generation malaria vaccine successfully implemented in three African countries. Lancet . 2024;403(10437):1607-1609. DOI: 10.1016/s0140-6736(23)02892-1 Day C.J et al. The essential malaria protein Pf CyRPA [...] well as host factors elicited by subunit and whole parasite vaccines against tuberculosis (TB) and malaria. Clinical trials are performed with our partners of the Ifakara Health Institute in Bagamoyo. Further [...] particularly TB. Unit researchers also work to understand the...
The effect of novel mosquito bite prevention tools on <em>Anopheles minimus</em> landing and key secondary endpoints: semi-field evaluations in... (Publications)
Greater Mekong Subregion (GMS) aims to eliminate all human malaria by 2030 and is making substantial progress toward this goal, with malaria increasingly confined to forest foci. These transmission foci [...] ions of the World Health Organization (WHO) on malaria elimination states that small population groups which constitute a large proportion of the malaria transmission reservoir should benefit from targeted [...] targeted strategies to reduce transmission overall. These population groups are...
Design, synthesis, and biological and crystallographic evaluation of novel inhibitors of <em>Plasmodium falciparum</em> enoyl-ACP-reductase... (Publications)
Malaria, a disease of worldwide significance, is responsible for over one million deaths annually. The liver-stage of Plasmodium's life cycle is the first, obligatory, but clinically silent step in malaria [...] development and has been regarded as a potential antimalarial target for the development of drugs for malaria prophylaxis and liver-stage eradication. In this paper, new coumarin-based triclosan analogues are
