Preclinical characterization and target validation of the antimalarial pantothenamide MMV693183 (Publications)
Drug resistance and a dire lack of transmission-blocking antimalarials hamper malaria elimination. Here, we present the pantothenamide MMV693183 as a first-in-class acetyl-CoA synthetase (AcAS) inhibitor [...] Pharmacokinetic-pharmacodynamic modelling predict that a single 30 mg oral dose is sufficient to cure a malaria infection in humans. Toxicology studies in rats indicate a > 30-fold safety margin in relation to [...] promising candidate for further (pre)clinical development with a novel...
<em>Ex vivo</em> interferon-gamma immune response to thrombospondin-related adhesive protein in coastal Kenyans: longevity and risk of <em>Plasmodium... (Publications)
against the subsequent development of malaria. Retesting of selected donors after one year showed a complete change in the reactivity pattern, suggesting that malaria-specific ex vivo IFN-gamma ELISPOT assay [...] conserved epitopes. This study provides important information regarding natural reactivity to a key malaria antigen
<em>Ex vivo</em> interferon-gamma immune response to thrombospondin-related adhesive protein in coastal Kenyans: longevity and risk of <em>Plasmodium... (Publications)
against the subsequent development of malaria. Retesting of selected donors after one year showed a complete change in the reactivity pattern, suggesting that malaria-specific ex vivo IFN-gamma ELISPOT assay [...] conserved epitopes. This study provides important information regarding natural reactivity to a key malaria antigen
Preclinical characterization and target validation of the antimalarial pantothenamide MMV693183 (Publications)
Drug resistance and a dire lack of transmission-blocking antimalarials hamper malaria elimination. Here, we present the pantothenamide MMV693183 as a first-in-class acetyl-CoA synthetase (AcAS) inhibitor [...] Pharmacokinetic-pharmacodynamic modelling predict that a single 30 mg oral dose is sufficient to cure a malaria infection in humans. Toxicology studies in rats indicate a > 30-fold safety margin in relation to [...] promising candidate for further (pre)clinical development with a novel...
Design, synthesis, and biological and crystallographic evaluation of novel inhibitors of <em>Plasmodium falciparum</em> enoyl-ACP-reductase... (Publications)
Malaria, a disease of worldwide significance, is responsible for over one million deaths annually. The liver-stage of Plasmodium's life cycle is the first, obligatory, but clinically silent step in malaria [...] development and has been regarded as a potential antimalarial target for the development of drugs for malaria prophylaxis and liver-stage eradication. In this paper, new coumarin-based triclosan analogues are
Parasite Chemotherapy (Page)
https://www.swisstph.ch/de/about/mpi/parasite-chemotherapy
African trypanosomes and malaria) and molecular approaches to drug action and resistance. The PCU works closely with product development partnerships such as the Medicines for Malaria Venture (MMV), DNDi or [...] 20 years of experience in assay development and drug efficacy testing for the causative agents of malaria (Plasmodium spp.), African sleeping sickness (Trypanosoma brucei), Chagas disease (T. cruzi), le [...] clinical candidates, including fexinidazole for human African trypanosomiasis...
Research Entities at Swiss TPH | Excellence in Science (Page)
https://www.swisstph.ch/de/research/research-entities
diseases such as malaria, parasitic worm infections, Buruli ulcer and tuberculosis. Clinical Immunology Malaria Gene Regulation Helminth Drug Development Helminth Immunology Malaria Host Interactions [...] Sensoring and Environmental Epidemiology Health Interventions Analytics and Intervention Modelling Malaria Epidemiology and Control Household Economics and Health Systems Research Health Systems and Policy
Molecular epidemiology and seroprevalence in asymptomatic <em>Plasmodium falciparum</em> infections of Malagasy pregnant women in the highlands (Publications)
BACKGROUND: Malaria epidemiology in Madagascar is classified into four different areas, ranging from unstable seasonal transmission in the highlands to hyperendemic perennial transmission areas in the [...] the costal level. Most malaria studies in Madagascar are focused on symptomatic children. However, because of the low transmission in some areas with correspondingly low level of semi-immunity, adults are [...] genetic epidemiology of malarial infections in pregnant women in order to provide...
Indigenous emergence and spread of <em>kelch13</em> C469Y artemisinin-resistant <em>Plasmodium falciparum</em> in Uganda (Publications)
As part of the Community Access to Rectal Artesunate for Malaria project, we collected blood samples from 697 children with signs of severe malaria in northern Uganda between 2018 and 2020, before and after [...] Artemisinin-based combination therapies (ACTs) were introduced as the standard of care for uncomplicated malaria in Africa almost two decades ago. Recent studies in East Africa have reported a gradual increase [...] geographic origin of k13 mutations. Of the 697 children, 540 were...
Safety and differential antibody and T-cell responses to <em>Plasmodium falciparum</em> sporozoite vaccine by age in Tanzanian adults, adolescents,... (Publications)
2016, there were more cases and deaths caused by malaria globally than in 2015. An effective vaccine would be an ideal additional tool for reducing malaria's impact. Sanaria((R)) PfSPZ Vaccine, composed [...] (SPZ) has been well tolerated and safe in malaria-naive and experienced adults in the United States and Mali and protective against controlled human malaria infection with Pf in the United States and
