Cause-specific mortality rates in sub-Saharan Africa and Bangladesh (Publications)
to noncommunicable diseases, and little malaria. HIV dominates in causes of mortality in the South African sites, which contrast with those in highly malaria endemic sites elsewhere in sub-Saharan Africa [...] diseases to mortality in sub-Saharan Africa are lower than has been previously suggested, while malaria is of relatively greater importance. CONCLUSION: The different patterns of mortality we identified
A large <em>Plasmodium vivax</em> reservoir and little population structure in the South Pacific (Publications)
INTRODUCTION: The importance of Plasmodium vivax in malaria elimination is increasingly being recognized, yet little is known about its population size and population genetic structure in the South Pacific [...] Pacific, an area that is the focus of intensified malaria control. METHODS: We have genotyped 13 microsatellite markers in 295 P. vivax isolates from four geographically distinct sites in Papua New Guinea [...] in sharp contrast to results from regions of low P. vivax endemicity. Prior...
Detection of antibodies to <em>Plasmodium falciparum</em> sporozoites by employing synthetic peptides (Publications)
A new achievement in the immunodiagnosis of malaria has been reached after the knowledge of the molecular structure of some plasmodial antigens has become available. One example is given by the repetitive [...] immunosorbent assay (ELISA) for the detection of antisporozoite antibodies in individuals from malaria-endemic countries. This (NANP)40 ELISA has been employed in a longitudinal study in a rural community [...] and can be useful for monitoring the immune status of populations...
Cause-specific mortality rates in sub-Saharan Africa and Bangladesh (Publications)
to noncommunicable diseases, and little malaria. HIV dominates in causes of mortality in the South African sites, which contrast with those in highly malaria endemic sites elsewhere in sub-Saharan Africa [...] diseases to mortality in sub-Saharan Africa are lower than has been previously suggested, while malaria is of relatively greater importance. CONCLUSION: The different patterns of mortality we identified
Nicolas Brancucci (People)
https://www.swisstph.ch/de/staff/profile/people/nicolas-brancucci
TPH to establish new drug screening approaches and to search for malaria transmission-blocking drugs. Since 2020, he is leading the “Malaria Host Interactions” research unit at the Swiss THP and holds a [...] Brancucci is a parasitologist particularly interested in studying molecular interactions between malaria parasites and their human host cells. In current projects, his team studies nutrient sensing and
New Vector Control Interventions (Page)
https://www.swisstph.ch/de/about/eph/vector-biology/new-vector-control-interventions
al. A review of selective indoor residual spraying for malaria control. Malar J . 2024;23:252. DOI: 10.1186/s12936-024-05053-3 Related Topics Malaria Urban Health Related Activities Clinical Trials Preclinical [...] Access (ViALLIN MUsAcc) Long-lasting insecticidal nets (LLINs), or bed nets, are the mainstay of malaria control. However, more than 50% of people living in endemic areas are currently unprotected because [...] expected lifespan. The aim of this project is to develop a digital tool...
Emergence of FY*A(null) in a <em>Plasmodium vivax</em>-endemic region of Papua New Guinea (Publications)
Human genetic polymorphisms of this nature are common in malarious regions, and all four human malaria parasites are holoendemic below 1500 meters in PNG. At this elevation, a prominent condition cha [...] demonstrated that alpha(+)-thalassemia is associated with increased susceptibility to uncomplicated malaria among young children. It is further proposed that alpha(+)-thalassemia may facilitate so- called [...] vivax infection to act later in life as a "natural vaccine" against severe...
A review of the frequencies of <em>Plasmodium falciparum</em> Kelch 13 artemisinin resistance mutations in Africa (Publications)
failure, except for Rwanda. These mutations present a threat to malaria control across the continent, since the greatest burden of malaria remains in Africa. A rise in the frequency of these mutations and [...] Plasmodium falciparum Kelch 13 (Pfk13), 7 years ago has provided an invaluable tool for monitoring AR in malaria endemic countries. Molecular Pfk13 surveillance revealed the resistance foci in the Greater Mekong [...] and their spread would reverse the gains made in the reduction of malar...
A review of the frequencies of <em>Plasmodium falciparum</em> Kelch 13 artemisinin resistance mutations in Africa (Publications)
failure, except for Rwanda. These mutations present a threat to malaria control across the continent, since the greatest burden of malaria remains in Africa. A rise in the frequency of these mutations and [...] Plasmodium falciparum Kelch 13 (Pfk13), 7 years ago has provided an invaluable tool for monitoring AR in malaria endemic countries. Molecular Pfk13 surveillance revealed the resistance foci in the Greater Mekong [...] and their spread would reverse the gains made in the reduction of malar...
Emergence of FY*A(null) in a <em>Plasmodium vivax</em>-endemic region of Papua New Guinea (Publications)
Human genetic polymorphisms of this nature are common in malarious regions, and all four human malaria parasites are holoendemic below 1500 meters in PNG. At this elevation, a prominent condition cha [...] demonstrated that alpha(+)-thalassemia is associated with increased susceptibility to uncomplicated malaria among young children. It is further proposed that alpha(+)-thalassemia may facilitate so- called [...] vivax infection to act later in life as a "natural vaccine" against severe...
