Analysis of diagnostic findings from the European mobile laboratory in Gueckedou, Guinea, March 2014 through March 2015 (Publications)
2015. METHODS: The unit diagnosed EVD and malaria, using the RealStar Filovirus Screen reverse transcription-polymerase chain reaction (RT-PCR) kit and a malaria rapid diagnostic test, respectively. RESULTS:
Nicolas Brancucci Professor an der Universität Basel (News)
https://www.swisstph.ch/de/news/news-detail-1/news/nicolas-brancucci-professor-an-der-universitaet-basel
Universität Basel, wo er die epigenetischen Mechanismen untersuchte, die die antigene Variation des Malaria-Parasiten Plasmodium falciparum kontrollieren. Anschliessend forschte er als Postdoc in Boston (Harvard [...] Glasgow (Wellcome Centre for Integrative Parasitology), wo er sich auf den Prozess der Entstehung des Malaria-Übertragungsstadiums konzentrierte. Brancuccis Forschung befasst sich mit der Art und Weise, wie
KALUMI - A Phase 2 Study on KAF156-Lumefantrine-SDF for acute uncomplicated Plasmodium falciparum in children (Projects)
https://www.swisstph.ch/de/projects/project-detail/project/kalumi-a-phase-2-study-on-kaf156-lumefantrine-sdf-for-acute-uncomplicated-plasmodium-falciparum-in-children
KAF156 and Lumefantrine-SDF combination in the treatment of acute uncomplicated Plasmodium falciparum Malaria. This study aims to confirm the efficacy, safety and tolerability of KLU156, a fixed dose combination [...] and children ≥ 5 kg body weight and ≥ 2 months of age suffering from uncomplicated P. falciparum malaria (with or without other Plasmodium spp. co-infection).
Next generation chemiluminescent probes for antimalarial drug discovery (Publications)
Malaria is caused by parasites of the Plasmodium genus and remains one of the most pressing human health problems. The spread of parasites resistant to or partially resistant to single or multiple drugs [...] frontline antimalarial artemisinin and its derivatives, poses a serious threat to current and future malaria control efforts. In vitro drug assays are important for identifying new antimalarial compounds and [...] detection limit of less than 100 parasites of the presented biosensor system...
Comparison of analytical methods for the evaluation of antibody responses against epitopes of polymorphic protein antigens (Publications)
Surface exposed protein antigens of the malaria parasite Plasmodium falciparum frequently harbor multiple dimorphic amino acid positions. These are associated with parasite immune evasion and represent [...] the humoral immune response against a semiconserved sequence (YX(44)LFX(47)KEKMX(52)L) of the key malaria blood stage vaccine candidate merozoite surface protein-1 (MSP-1). Monoclonal antibodies (mAbs) raised [...] MSP-1(43-53) variant sequences. When used for the evaluation of humoral...
Artemisinins and synthetic trioxolanes in the treatment of helminth infections (Publications)
following recommended malaria treatment schedules, found an effect against schistosomiasis. SUMMARY: Artemisinin-based combination therapies are increasingly deployed against malaria, and hence there is [...] that artemisinin-based combination therapy might have on trematode infections in settings where malaria and helminthiases are co-endemic. RECENT FINDINGS: The artemisinins and synthetic trioxolanes possess
WHO Collaborating Centres (Page)
https://www.swisstph.ch/de/research/who-collaborating-centres
for Modelling, Monitoring and Training for Malaria Control and Elimination The purpose of the Collaboration Centre is to provide technical advice, improve malaria prevention modelling methods, evaluate routine [...] Diseases and Programmes Unit. The WHO Collaborating Centre for Modelling, Monitoring and Training for Malaria Control and Elimination is based in the Health Interventions Unit. The WHO Collaborating Centre for
Next generation chemiluminescent probes for antimalarial drug discovery (Publications)
Malaria is caused by parasites of the Plasmodium genus and remains one of the most pressing human health problems. The spread of parasites resistant to or partially resistant to single or multiple drugs [...] frontline antimalarial artemisinin and its derivatives, poses a serious threat to current and future malaria control efforts. In vitro drug assays are important for identifying new antimalarial compounds and [...] detection limit of less than 100 parasites of the presented biosensor system...
Comparison of analytical methods for the evaluation of antibody responses against epitopes of polymorphic protein antigens (Publications)
Surface exposed protein antigens of the malaria parasite Plasmodium falciparum frequently harbor multiple dimorphic amino acid positions. These are associated with parasite immune evasion and represent [...] the humoral immune response against a semiconserved sequence (YX(44)LFX(47)KEKMX(52)L) of the key malaria blood stage vaccine candidate merozoite surface protein-1 (MSP-1). Monoclonal antibodies (mAbs) raised [...] MSP-1(43-53) variant sequences. When used for the evaluation of humoral...
Artemisinins and synthetic trioxolanes in the treatment of helminth infections (Publications)
following recommended malaria treatment schedules, found an effect against schistosomiasis. SUMMARY: Artemisinin-based combination therapies are increasingly deployed against malaria, and hence there is [...] that artemisinin-based combination therapy might have on trematode infections in settings where malaria and helminthiases are co-endemic. RECENT FINDINGS: The artemisinins and synthetic trioxolanes possess
