A novel multiple-stage antimalarial agent that inhibits protein synthesis (Publications)
There is an urgent need for new drugs to treat malaria, with broad therapeutic potential and novel modes of action, to widen the scope of treatment and to overcome emerging drug resistance. Here we describe [...] blocking and chemoprotection. DDD107498 was developed from a screening programme against blood-stage malaria parasites; its molecular target has been identified as translation elongation factor 2 (eEF2), which
Multiplex assay for species identification and monitoring of insecticide resistance in <em>Anopheles punctulatus</em> group populations of Papua New... (Publications)
complex [eight cryptic species]) are principal vectors of malaria and filariasis in the Southwest Pacific. Given significant effort to reduce malaria and filariasis transmission through insecticide-treated
dUTPase as a platform for antimalarial drug design: structural basis for the selectivity of a class of nucleoside inhibitors (Publications)
route for therapeutic intervention against malaria. Here we report inhibition and structural studies on the deoxyuridine nucleotidohydrolase from the malaria parasite Plasmodium falciparum (PfdUTPase)
Discovery and characterization of ACT-451840: an antimalarial drug with a novel mechanism of action (Publications)
More than 40 % of the world's population is at risk of being infected with malaria. Most malaria cases occur in the countries of sub-Saharan Africa, Central and South America, and Asia. Resistance to standard
Systematic review of indoor residual spray efficacy and effectiveness against <em>Plasmodium falciparum</em> in Africa (Publications)
Indoor residual spraying (IRS) is an important part of malaria control. There is a growing list of insecticide classes; pyrethroids remain the principal insecticide used in bednets but recently, novel [...] of different IRS insecticides. We report that long-lasting IRS formulations substantially reduce malaria, though their benefit over cheaper, shorter-lived formulations depends on local factors including
Medicines Development | Research at Swiss TPH (Page)
https://www.swisstph.ch/de/about/med/medicines-development
platforms, malaria drug resistance genotyping services and the development of vaccines and treatments for tropical infectious diseases. The MDU excels in providing global genotyping services for malaria resistance [...] on diseases such as malaria, respiratory viruses, Buruli ulcer and undifferentiated febrile diseases. Our Core Competencies Our core expertise is in molecular genotyping for malaria drug resistance testing [...] testing, diagnostic development of non-invasive and innovative...
Basic Research in Infection Biology | Swiss TPH (Page)
https://www.swisstph.ch/de/research/basic-research-in-infection-biology
are neglected tropical diseases that affect the poorest communities. Malaria A gametocyte - the sexual form of Plasmodium Malaria is caused by unicellular parasites of the genus Plasmodium , which are [...] Infection Biology conduct cutting-edge basic research on infectious diseases of poverty, including Malaria (caused by Plasmodium spp .) Tuberculosis (caused by Mycobacterium tuberculosis ) Buruli ulcer (caused [...] Mycobacterium ulcerans ) Sleeping sickness/African trypanosomiasis (caused...
Diagnostik-Zentrum | Expertise für parasitäre Krankheiten am Swiss TPH (Page)
https://www.swisstph.ch/de/services/diagnostik-zentrum
Nachmittag geschlossen bleibt. Abschaffung Malaria Pikettdienst am Abend, Wochenende und Feiertagen! Das Diagnostik-Zentrum wird ab dem 01.03.2025 keinen Malaria-Mikroskopie Notfalldienst mehr am Abend, [...] seltene Parasitosen zu untersuchen. Untersuchungsauftrag Untersuchungsangebot Methoden und Material Malaria-Notfalldienst Nationales Referenzzentrum Das Diagnostik-Zentrum des Swiss TPH ist das Nationale [...] 13:00–17:00) Tel. +41 61 284 82 56 Fax +41 61 284 81 18 Email: labor@swisstph.ch...
Surveillance of molecular markers of <em>Plasmodium falciparum</em> artemisinin resistance (<em>kelch</em>13 mutations) in Papua New Guinea between... (Publications)
Plasmodium falciparum resistance to artemisinin-based combination therapy (ACT) is a global threat to malaria control and elimination efforts. Mutations in the P. falciparum kelch13 gene (Pfk13) that are associated [...] in other parts of PNG is unknown. We investigated the prevalence of Pfk13 mutations in multiple malaria-endemic regions of PNG. P. falciparum isolates (n = 1152) collected between 2016 and 2018 and assessed [...] Continued surveillance for molecular markers of drug resistance is...
Human exposure to anopheline mosquitoes occurs primarily indoors, even for users of insecticide-treated nets in Luangwa Valley, south-east Zambia (Publications)
insecticidal products. We studied the human biting behaviour of the malaria vector Anopheles funestus Giles and the potential malaria vector Anopheles quadriannulatus Theobald in Luangwa valley, south-east [...] ABSTRACT: BACKGROUND: Current front line malaria vector control methods such as indoor residual spraying (IRS) and long-lasting insecticidal nets (LLINs), rely upon the preference of many primary vectors
