Synthesis and structure-activity relationships of new 2-phenoxybenzamides with antiplasmodial activity (Publications)
The 2-phenoxybenzamide 1 from theMedicines for Malaria Venture Malaria Box Project has shown promising multi-stage activity against different strains of P. falciparum. It was successfully synthesized via
Molecular surveillance of the antifolateresistant mutation I164L in imported African isolates of <em>Plasmodium falciparum</em> in Europe: sentinel... (Publications)
BACKGROUND: Malaria parasites that carry the DHFR-mutation I164L are not only highly resistant to sulfadoxine-pyrimethamine but also to the new antimalarial drug chlorproguanil-dapsone. The spread of this [...] network for the surveillance of travel-associated diseases and seems to cover approximately 12% of all malaria cases imported into Europe. Within this network we screened 277 imported African isolates of P.
Cytotoxic T lymphocyte (CTL) low-responsiveness to the <em>Plasmodium falciparum</em> circumsporozoite protein in naturally-exposed endemic... (Publications)
epitope(s) within the circumsporozoite (CS) protein of malaria sporozoites have been shown to play an important role in protective immunity against malaria, at least in murine models. Their role in sporozoite
Field-caught permethrin-resistant <em>Anopheles gambiae</em> overexpress CYP6P3, a P450 that metabolises pyrethroids (Publications)
Resistance to pyrethroid insecticides in the malaria vector Anopheles gambiae is receiving increasing attention because it threatens the sustainability of malaria vector control programs in sub-Saharan Africa
Epidemiology of multiple <em>Plasmodium falciparum</em> infections. 6. Multiple <em>Plasmodium falciparum</em> infections in Tanzanian infants (Publications)
clinical malaria, in contrast to the situation in older children (> 2 years). The findings help in the understanding of infection dynamics, premunition, and development of semi-immunity in malaria.
A community-randomized evaluation of the effect of intermittent preventive treatment in infants on antimalarial drug resistance in southern Tanzania (Publications)
is the administration of sulphadoxine-pyrimethamine (SP) at 2, 3 and 9 months of age to prevent malaria. We investigated the influence of IPTi on drug resistance.Methods. Twenty-four areas were randomized [...] did not increase drug pressure, or the selection on dhfr and dhps mutants, when SP was first line malaria treatment. Introduction of artemether-lumefantrine was followed by an increase in dhfr mutations
Targeting <em>Plasmodium </em>plasmepsin V: hitting two birds with one stone (Publications)
al. reveals an important role for plasmepsin V (PMV), an aspartyl protease, in the development of malaria transmission stages. The authors showed that PMV activity is critical for protein export in these
Targeting <em>Plasmodium </em>plasmepsin V: hitting two birds with one stone (Publications)
al. reveals an important role for plasmepsin V (PMV), an aspartyl protease, in the development of malaria transmission stages. The authors showed that PMV activity is critical for protein export in these
Long-term acceptability, durability and bio-efficacy of ZeroVector® durable lining for vector control in Papua New Guinea (Publications)
had previously been installed in 40 homes across four study sites representing a cross section of malaria transmission risk and housing style. Structured questionnaires, DL visual inspections and group [...] at 36-months post-installation, the material and fixtures proved durable and the efficacy against malaria vectors did not decrease. However, the DL material had been removed from over 50% of the original [...] suggest DL may not be an appropriate vector control method for large-scale use in...
Determinants of bed net use conditional on access in population surveys in Ghana (Publications)
e-treated nets (ITNs) are one of the most effective and widely available methods for preventing malaria, and there is interest in understanding the complexities of behavioural drivers of non-use among [...] access to a net. METHODS: Survey data from the Ghana 2014 Demographic and Health Survey and the 2016 Malaria Indicator Survey were used to calculate household members' access to space under a net as well as [...] households when compared to the poorest category. In 2014, exposure to messages...
