Long-term trends in <em>Anopheles gambiae</em> insecticide resistance in Côte d'Ivoire (Publications)
for ITNs. The rapid rise in insecticide resistance in African malaria vectors has raised alarms about the sustainability of existing malaria control activities. This problem might be particularly acute [...] BackgroundMalaria control is heavily dependent on the use of insecticides that target adult mosquito vectors via insecticide treated nets (ITNs) or indoor residual spraying (IRS). Four classes of insecticide
Comparison of detection methods to estimate asexual <em>Plasmodium falciparum</em> parasite prevalence and gametocyte carriage in a community survey... (Publications)
BACKGROUND: The use of molecular techniques to detect malaria parasites has been advocated to improve the accuracy of parasite prevalence estimates, especially in moderate to low endemic settings. Molecular [...] carefully evaluated. Light microscopy (LM) and rapid diagnostic tests (RDT) are commonly used to detect malaria infection in resource constrained areas, but their limited sensitivity results in underestimation [...] identified by PCR. Thus, LM is not a sufficiently accurate technique...
Effect of vitamin A supplementation on morbidity due to <em>Plasmodium falciparum</em> in young children in Papua New Guinea: a randomised trial (Publications)
BACKGROUND: Many individuals at risk of malaria also have micronutrient deficiencies that may hamper protective immunity. Vitamin A is central to normal immune function, and supplementation has been shown [...] morbidity of some infectious diseases. We investigated the effect of vitamin A supplementation on malaria morbidity. METHODS: This randomised double-blind placebo-controlled trial of vitamin A supplementation [...] randomly assigned high-dose vitamin A (n=239) or placebo (n=241), every 3...
Long-term acceptability, durability and bio-efficacy of ZeroVector® durable lining for vector control in Papua New Guinea (Publications)
had previously been installed in 40 homes across four study sites representing a cross section of malaria transmission risk and housing style. Structured questionnaires, DL visual inspections and group [...] at 36-months post-installation, the material and fixtures proved durable and the efficacy against malaria vectors did not decrease. However, the DL material had been removed from over 50% of the original [...] suggest DL may not be an appropriate vector control method for large-scale use in...
Mosquito net coverage in years between mass distributions: a case study of Tanzania, 2013 (Publications)
commercial market. To sustain investments and health gains in the fight against malaria, it is important for the National Malaria Control Programme to monitor LLIN coverage especially in the years between mass [...] household survey was conducted in 3398 households in eight districts in Tanzania. Using the Roll Back Malaria indicators, the study analysed: (1) household net ownership; (2) access to nets; (3) population net
Determinants of bed net use conditional on access in population surveys in Ghana (Publications)
e-treated nets (ITNs) are one of the most effective and widely available methods for preventing malaria, and there is interest in understanding the complexities of behavioural drivers of non-use among [...] access to a net. METHODS: Survey data from the Ghana 2014 Demographic and Health Survey and the 2016 Malaria Indicator Survey were used to calculate household members' access to space under a net as well as [...] households when compared to the poorest category. In 2014, exposure to messages...
First-trimester artemisinin derivatives and quinine treatments and the risk of adverse pregnancy outcomes in Africa and Asia: a meta-analysis of... (Publications)
artemisinin combination therapy regimens to treat malaria in early pregnancy are likely to outweigh the adverse outcomes of partially treated malaria, which can occur with oral quinine because of the known [...] safety data in human pregnancies, have prevented artemisinin derivatives from being recommended for malaria treatment in the first trimester except in lifesaving circumstances. We conducted a meta-analysis [...] antimalarial treatment. METHODS AND FINDINGS: Electronic databases including...
First-trimester artemisinin derivatives and quinine treatments and the risk of adverse pregnancy outcomes in Africa and Asia: a meta-analysis of... (Publications)
artemisinin combination therapy regimens to treat malaria in early pregnancy are likely to outweigh the adverse outcomes of partially treated malaria, which can occur with oral quinine because of the known [...] safety data in human pregnancies, have prevented artemisinin derivatives from being recommended for malaria treatment in the first trimester except in lifesaving circumstances. We conducted a meta-analysis [...] antimalarial treatment. METHODS AND FINDINGS: Electronic databases including...
Prospective risk of morbidity in relation to multiplicity of infection with <em>Plasmodium falciparum </em>in Sao Tomé (Publications)
confounding by patterns of health service usage is an alternative explanation. The incidence of clinical malaria episodes was only a little higher in children than in adults. This weak age-dependence in clinical [...] a consequence of a cohort effect resulting from resurgence of the disease after the breakdown of malaria control programs in the 1980s.
Activity refinement of aryl amino acetamides that target the <em>P. falciparum</em> STAR-related lipid transfer 1 protein (Publications)
Malaria is a devastating disease that causes significant morbidity worldwide. The development of new antimalarial chemotypes is urgently needed because of the emergence of resistance to frontline therapies [...] a useful tool for further investigating the druggability of PfSTART1 across the lifecycle of the malaria parasite.
