Additional blood meals increase sporozoite infection in <em>Anopheles</em> mosquitoes but not <em>Plasmodium falciparum</em> genetic diversity (Publications)
multiple blood meals on the number of P. falciparum genotypes developing from polyclonal natural human malaria infections (field-isolates) remains unexplored. Here, we experimentally infect An. gambiae with P
Inhibitors of adenosine consuming parasites through polymer-assisted solution phase synthesis of lipophilic 5'-amido-5'-deoxyadenosine... (Publications)
structurally diverse starting points for the development of chemotherapeutic agents for the treatment of malaria are urgently needed. Thus, a series of 20 adenosine derivatives with a large lipophilic substituent
Optimization of 4-aminoquinoline/clotrimazole-based hybrid antimalarials: further structure-activity relationships, in vivo studies, and preliminary... (Publications)
Despite recent progress in the fight against malaria, the emergence and spread of drug-resistant parasites remains a serious obstacle to the treatment of infections. We recently reported the development
Rapid mapping of schistosomiasis and other neglected tropical diseases in the context of integrated control programmes in Africa (Publications)
lessons from the mapping of human helminth infections may also be relevant for the rapid mapping of malaria as its control efforts are intensified
Blood schizontocidal and gametocytocidal activity of 3-hydroxy-N'-arylidenepropanehydrazonamides: a new class of antiplasmodial compounds (Publications)
moiety, demonstrated in vivo antiplasmodial activity after oral administration in a P. berghei malaria model, although no complete parasite elimination was achieved with a four-dose regimen. The in vivo
Inhibition of <em>Plasmodium falciparum</em> Hsp90 contributes to the antimalarial activities of aminoalcohol-carbazoles (Publications)
Malaria caused by the protozoan parasite Plasmodium falciparum (Pf) remains a major public health problem throughout the developing world. One molecular target that should receive more attention is the
Decreased in vitro susceptibility of <em>Plasmodium falciparum</em> isolates to artesunate, mefloquine, chloroquine, and quinine in Cambodia from 2001... (Publications)
from patients enrolled in therapeutic efficacy studies (TES) conducted by the Cambodian National Malaria Control Program for the routine efficacy monitoring of artemisinin-based combination therapy (ACT)
Mosquito nets and the poor: can social marketing redress inequities in access? (Publications)
Treated mosquito nets are a practical malaria control tool. However, implementation of efficient delivery mechanisms remains a challenge. We investigated whether social marketing of treated mosquito nets
Antiprotozoal activities of some constituents of <em>Markhamia tomentosa</em> (Bignoniaceae) (Publications)
bloodstream trypomastigotes of Trypanosoma brucei rhodesiense (the species responsible for human malaria, visceral leishmaniasis and African trypanosomiasis, respectively). Although compounds 1 and 2 exhibited
Antiprotozoal activities of traditional medicinal plants from the Garhwal region of North West Himalaya, India (Publications)
Garhwal region of North West Himalaya for the treatment of protozoal infections and fever including malaria. MATERIALS AND METHODS: In vitro activity against erythrocytic stages of Plasmodium falciparum was
