Management of severe malaria cases learnings and challenges from the field (Publications)
A presentation on the management of severe malaria cases learnings and challenges from the field by Manuel Hetzel of the CARAMAL project.
Mining Sudanese medicinal plants for natural compounds against malaria and neglected tropical diseases (Publications)
Tropical parasitic diseases such as malaria, human African trypanosomiasis, Chagas disease, mycetoma, and leishmaniasis affect more than a billion people worldwide and have devastating consequences. There
Investigation of heterochromatin protein 1 function in the malaria parasite <em>Plasmodium falciparum</em> using a conditional domain deletion and... (Publications)
offers a tool for further studies on epigenetic regulation and life cycle decision in malaria parasites.IMPORTANCE Malaria is caused by unicellular Plasmodium species parasites that repeatedly invade and replicate [...] The human malaria parasite Plasmodium falciparum encodes a single ortholog of heterochromatin protein 1 (PfHP1) that plays a crucial role in the epigenetic regulation of various survival-related processes [...] domain and CSD of HP1 are functionally conserved between P....
Effect of deworming on school-aged children's physical fitness, cognition and clinical parameters in a malaria-helminth co-endemic area of Côte... (Publications)
BACKGROUND: Malaria and helminth infections are thought to negatively affect children's nutritional status and to impair their physical and cognitive development. Yet, the current evidence-base is weak [...] helminthiasis and schistosomiasis on children's physical fitness, cognition and clinical parameters in a malaria-helminth co-endemic setting of Cote d'Ivoire. METHODS: We designed an intervention study with a 5-month [...] speculate that potential beneficial effects of deworming are likely...
An experimental hut study to quantify the effect of DDT and airborne pyrethroids on entomological parameters of malaria transmission (Publications)
BACKGROUND: Current malaria vector control programmes rely on insecticides with rapid contact toxicity. However, spatial repellents can also be applied to reduce man-vector contact, which might ultimately [...] ultimately impact malaria transmission. The aim of this study was to quantify effects of airborne pyrethroids from coils and DDT used an indoor residual spray (IRS) on entomological parameters that influence [...] influence malaria transmission. METHODS: The effect of Transfluthrin and...
A cluster-randomized controlled trial to assess the effectiveness of using 15% DEET topical repellent with long-lasting insecticidal nets (LLINs)... (Publications)
al nets (LLINs) have limited effect on malaria transmitted outside of sleeping hours. Topical repellents have demonstrated reduction in the incidence of malaria transmitted in the early evening. This study [...] likely a result of lack of statistical power, poor capture of malaria events or bias caused by imbalance in the SES of the two groups. Low malaria transmission during the study period could have masked the [...] study assessed whether 15% DEET topical repellent used in combination with...
Comparative assessment of diverse strategies for malaria vector population control based on measured rates at which mosquitoes utilize targeted... (Publications)
BACKGROUND: Eliminating malaria requires vector control interventions that dramatically reduce adult mosquito population densities and survival rates. Indoor applications of insecticidal nets and sprays
Efficacy and safety of the RTS,S/AS01 malaria vaccine during 18 months after vaccination: a phase 3 randomized, controlled trial in children and young... (Publications)
BACKGROUND: A malaria vaccine could be an important addition to current control strategies. We report the safety and vaccine efficacy (VE) of the RTS,S/AS01 vaccine during 18 mo following vaccination at [...] at 11 African sites with varying malaria transmission. METHODS AND FINDINGS: 6,537 infants aged 6-12 wk and 8,923 children aged 5-17 mo were randomized to receive three doses of RTS,S/AS01 or comparator [...] comparator vaccine. VE against clinical malaria in children during the 18 mo after...
Understanding private sector antimalarial distribution chains: a cross-sectional mixed methods study in six malaria-endemic countries (Publications)
BACKGROUND: Private for-profit outlets are important treatment sources for malaria in most endemic countries. However, these outlets constitute only the last link in a chain of businesses that includes