A public antibody lineage that potently inhibits malaria infection through dual binding to the circumsporozoite protein (Publications)
with attenuated Plasmodium falciparum sporozoites (PfSPZs) has been shown to be protective against malaria, but the features of the antibody response induced by this treatment remain unclear. To investigate [...] repeated injection of Sanaria PfSPZ Vaccine and who were found to be protected from controlled human malaria infection with infectious homologous PfSPZs. All isolated IgG monoclonal antibodies bound to P.
A review of spatial epidemiology with malaria surveillance and control in China (Publications)
monitoring and control of malaria depends largely on the spatial analysis technology and mathematical models. Visualization of malaria situation is the most popular way to present how malaria transmits. In this [...] paper, the malaria epidemic situation and the application of spatial epidemiology of malaria in China are summarized, so as to provide the systematic epidemiological information for malaria elimination
Small-scale field evaluation of push-pull system against early- and outdoor-biting malaria mosquitoes in an area of high pyrethroid resistance in... (Publications)
mortality in push-pull contexts. This approach, if optimised, could potentially complement existing malaria interventions even in areas with high pyrethroid resistance.
Immunization of malaria pre-exposed volunteers with PfSPZ Vaccine elicits long-lived IgM invasion-inhibitory and complement-fixing antibodies (Publications)
antibodies are induced following immunization of malaria pre-exposed volunteers with PfSPZ Vaccine. We found that in addition to anti-PfCSP IgG, Malaria pre-exposed volunteers developed anti-PfCSP IgM [...] and Pf sporozoite-binding IgM antibodies are induced following immunization of PfSPZ Vaccine in malaria pre-exposed individuals and that IgM antibodies can inhibit Pf sporozoite invasion into hepatocytes
The effect of case management and vector-control interventions on space-time patterns of malaria incidence in Uganda (Publications)
space-time patterns of malaria incidence in children < 5 are similar to those of parasitaemia risk predicted from the malaria indicator survey of 2014-15. CONCLUSION: The decline in malaria incidence highlights [...] METHODS: Bayesian spatio-temporal negative binomial models were fitted on district-aggregated monthly malaria cases, reported by two age groups, defined by a cut-off age of 5 years. The effects of interventions [...] trigonometric functions were incorporated in the models to take...
Using yeast synthetic lethality to inform drug combination for malaria (Publications)
Combinatorial chemotherapy is necessary for the treatment of malaria. However, finding a suitable partner drug for a new candidate is challenging. Here we develop an algorithm that identifies all of the
Challenges of DHS and MIS to capture the entire pattern of malaria parasite risk and intervention effects in countries with different ecological... (Publications)
multiple indicator cluster survey. Malaria parasitological data were collected, but the survey period did not overlap with the high malaria transmission season. A malaria indicator survey (MIS) was also conducted [...] conducted during the same year, within the malaria peak transmission season. This study compares estimates of the geographical distribution of malaria parasite risk and of the effects of interventions [...] used to identify the most important climatic predictors and indicators of ...
The impact of the scale-up of malaria rapid diagnostic tests on the routine clinical diagnosis procedures for febrile illness: a series of repeated... (Publications)
BACKGROUND: This paper examines the impact of the scale-up of malaria rapid diagnostic tests (RDT) on routine clinical diagnosis procedures for febrile illness in primary healthcare settings in Papua New [...] pre- and post-RDT scale-up and between febrile patients who tested either negative or positive for malaria infection by RDT (post scale-up only). RESULTS: A total of 1809 observations from 120 health facilities [...] scale-up has led to a reduction in body temperature measurement....
Screening a repurposing library, the Medicines for Malaria Venture Stasis Box, against <em>Schistosoma mansoni</em> (Publications)
development path, hence reducing costs and timelines. Promoting this approach, the Medicines for Malaria Venture (MMV) recently distributed a drug repurposing library of 400 advanced lead candidates (Stasis
