Model-informed target product profiles of long-acting-injectables for use as seasonal malaria prevention (Publications)
Seasonal malaria chemoprevention (SMC) has proven highly efficacious in reducing malaria incidence. However, the continued success of SMC is threatened by the spread of resistance against one of its main [...] and incomplete adherence to the regimens. Via a simulation study with an individual-based model of malaria dynamics, we provide quantitative evidence to assess long-acting injectables (LAIs) as potential
Health worker compliance with severe malaria treatment guidelines in the context of implementing pre-referral rectal artesunate in the Democratic... (Publications)
concerns about an effective continuum of care for children with severe malaria seem justified. Stricter compliance with the WHO severe malaria treatment guidelines is critical to effectively manage this disease [...] BACKGROUND: For a full treatment course of severe malaria, community-administered pre-referral rectal artesunate (RAS) should be completed by post-referral treatment consisting of an injectable antimalarial [...] admission in included referral health facilities (RHFs) in children...
Der lange Weg zur ersten Impfung gegen Malaria (Publications)
langen Weg: Die Weltgesundheitsorganisation hat jüngst den Einsatz des ersten Impfstoffes gegen Malaria zum breitflächigen Einsatz bei Kindern in den betroffenen Ländern empfohlen. Dennoch braucht es
Influence of testing modality on bioefficacy for the evaluation of Interceptor® G2 mosquito nets to combat malaria mosquitoes in Tanzania (Publications)
against pyrethroid-resistant strains, demonstrating the usefulness of chlorfenapyr in mitigation of malaria.
The impact of <em>Loa loa</em> microfilaraemia on research subject retention during a whole sporozoite malaria vaccine trial in Equatorial Guinea (Publications)
300 (2.7%) residents of Bioko Island, Equatorial Guinea, during a Plasmodium falciparum sporozoite malaria vaccine clinical trial. Only one subject was found to have microfilaraemia on his first exam; parasites
Prevalence and force of <em>Plasmodium vivax</em> blood-stage infection and associated clinical malaria burden in the Brazilian Amazon (Publications)
Understanding the epidemiology of malaria through the molecular force of the blood-stage infection of Plasmodium vivax (molFOB) may provide a detailed assessment of malaria transmission. OBJECTIVES: In this [...] ed risk factors and spatial-temporal patterns of incidence of Plasmodium infection and clinical malaria episodes in three peri-urban communities of Manaus, Western Brazilian Amazon. METHODS: Monthly samples [...] Subjects who reported possession of a bed net [incidence rate ratio (IRR)...
Knowledge, attitudes and practices towards malaria diagnostics among healthcare providers and healthcare-seekers in Kondoa district, Tanzania: a... (Publications)
large-scale rollout of malaria rapid diagnostic tests (RDTs) in Tanzania, many healthcare providers (HCPs) continue using blood film microscopy (BFM) and clinical examination to diagnose malaria, which can increase [...] survey, 48% preferred using BFM for malaria testing, while 52% preferred RDT. Faced with a negative RDT result for a patient presenting with symptoms typical for malaria, 25% of HCPs stated they would confirm [...] a concern. Frequent training and supportive supervision for HCPs...
The relative impact of interventions on sympatric <em>Plasmodium vivax</em> and <em>Plasmodium falciparum</em> malaria: a systematic review (Publications)
BACKGROUND: In areas with both Plasmodium vivax and Plasmodium falciparum malaria, interventions can reduce the burden of both species but the impact may vary due to their different biology. Knowing the [...] infections attributed to P. vivax over time using a literature search. The change in the proportion of malaria attributed to P. vivax up to two years since implementation was estimated using logistic regression [...] insufficient information on interventions. There was considerable...
High-throughput <em>Plasmodium falciparum hrp2</em> and <em>hrp3 </em>gene deletion typing by digital PCR to monitor malaria rapid diagnostic test... (Publications)
Plasmodium falciparum malaria target the Histidine-Rich Proteins 2 and 3 (HRP2, HRP3). Deletions of the hrp2 and hrp3 genes result in false negative tests and are a threat for malaria control. A novel assay
