Potential causes and consequences of behavioural resilience and resistance in malaria vector populations: a mathematical modelling analysis (Publications)
evade fatal exposure to insecticidal nets and sprays represents the primary obstacle to eliminating malaria. However, it remains unclear which behaviours are most important for buffering mosquito and parasite
Efficacy and safety of dihydroartemisinin-piperaquine for treatment of <em>Plasmodium vivax</em> malaria in endemic countries: meta-analysis of... (Publications)
the efficacy of dihydroartemisinin-piperaquine (DHP) in treating uncomplicated Plasmodium vivax malaria in people living in endemic countries. METHODOLOGY AND PRINCIPAL FINDINGS: This is a meta-analysis [...] Findings document that DHP is more efficacious than CQ and AL in treating uncomplicated P. vivax malaria. The better safety profile of DHP and the once-daily dosage improves adherence, and its fixed co [...] the potential to become an alternative antimalarial drug for the treatment...
Orally active antischistosomal early leads identified from the open access malaria box (Publications)
drugs. METHODOLOGY: We studied the antischistosomal properties of the Medicines for Malaria Venture (MMV) malaria box containing 200 diverse drug-like and 200 probe-like compounds with confirmed in vitro [...] respectively. CONCLUSIONS/SIGNIFICANCE: The two candidates identified by investigating the MMV malaria box are characterized by good pharmacokinetic profiles, low cytotoxic potential and easy chemistry
Malaria case management in Papua New Guinea following the introduction of a revised treatment protocol (Publications)
fever or suspected malaria patients and via an interviewer administered questionnaire completed with the officer in charge of each participating health care facility. RESULTS: Malaria rapid diagnostic tests [...] 445) were tested for malaria by RDT and 39% prescribed an anti-malarial, inclusive of 98.2% of RDT positive patients and 19.8% of RDT negative cases. The availability and use of malaria RDTs was greater in [...] CONCLUSIONS: PNG has achieved high coverage of malaria RDTs and AL at the...
Naturally acquired immune responses to <em>P. vivax</em> merozoite surface protein 3alpha and merozoite surface protein 9 are associated with reduced... (Publications)
is the most geographically widespread human malaria parasite. Cohort studies in Papua New Guinea have identified a rapid onset of immunity against vivax-malaria in children living in highly endemic areas [...] and Merozoite Surface Protein 9 (PvMSP9) were measured and related to prospective risk of P. vivax malaria during 16 months of active follow-up. Overall, there was a low prevalence of antibodies to PvMSP3alpha [...] PvMSP9 N-terminus (aIRR = 0.68, p = 0.035) were associated with protection...
Seeking treatment for symptomatic malaria in Papua New Guinea (Publications)
reported suffering from malaria in the previous four weeks. A probit model was then used to identify the factors determining whether or not people sought treatment for presumptive malaria. Multinomial logit [...] BACKGROUND: Malaria places a significant burden on the limited resources of many low income countries. Knowing more about why and where people seek treatment will enable policy makers to better allocate [...] resources. This study aims to better understand what influences...
Malaria Policy Advisory Committee to the WHO: conclusions and recommendations of March 2013 meeting (Publications)
resource allocation for malaria control; malaria surveillance and the need for a surveillance, monitoring and evaluation Technical Expert Group; criteria and classification related to malaria elimination; the [...] Suriname; the outcomes from a consultation on non-malaria febrile illness; the outcomes from the second meeting of the Evidence Review Group on malaria burden estimation; an update on the review of the [...] Guidelines for the Treatment of Malaria; an update regarding progress on the...
Organellar proteomics reveals hundreds of novel nuclear proteins in the malaria parasite <em>Plasmodium falciparum</em> (Publications)
BACKGROUND: The post-genomic era of malaria research provided unprecedented insights into the biology of Plasmodium parasites. Due to the large evolutionary distance to model eukaryotes, however, we lack [...] serve as an important platform for dissecting general and parasite-specific nuclear processes in malaria parasites. Moreover, as the first nuclear proteome characterized in any protist organism, it will
Health worker factors associated with prescribing of artemisinin combination therapy for uncomplicated malaria in rural Tanzania (Publications)
uncomplicated malaria defined as prescription of artemisinin-based combination therapy (ACT) for patients with fever and Plasmodium falciparum asexual infection based on blood slide or malaria rapid diagnostic [...] patients with uncomplicated malaria who were seen in a health facility with ACT in stock, and 71 health workers practicing in 30 health facilities. Overall, 58% of malaria patients were correctly treated [...] with correct ACT prescription for uncomplicated malaria. Targeted...
Correct dosing of artemether-lumefantrine for management of uncomplicated malaria in rural Tanzania: do facility and patient characteristics matter? (Publications)
requires a strict dosing schedule that follows the drugs' pharmacokinetic properties. The quality of malaria case management was assessed in two areas in rural Tanzania, to ascertain patient characteristics [...] and facility-specific factors that influence correct dosing of AL for management of uncomplicated malaria. METHODS: Exit interviews were conducted with patients attending health facilities for initial illness [...] facilities were inventoried for capacity and availability of medical...