Open source drug discovery with the malaria box compound collection for neglected diseases and beyond (Publications)
A major cause of the paucity of new starting points for drug discovery is the lack of interaction between academia and industry. Much of the global resource in biology is present in universities, wher
Discovery of a quinoline-4-carboxamide derivative with a novel mechanism of action, multistage antimalarial activity, and potent in vivo efficacy (Publications)
The antiplasmodial activity, DMPK properties, and efficacy of a series of quinoline-4-carboxamides are described. This series was identified from a phenotypic screen against the blood stage of Plasmod
Validation of a rapid rabies diagnostic tool for field surveillance in developing countries (Publications)
BACKGROUND: One root cause of the neglect of rabies is the lack of adequate diagnostic tests in the context of low income countries. A rapid, performance friendly and low cost method to detect rabies
Is zidovudine first line therapy virologically comparable to tenofovir in resource-limited settings? (Publications)
OBJECTIVE: To compare virologic success between adult patients on tenofovir (TDF) and zidovudine (AZT)-containing first-line anti-retroviral (ART) regimens in 10 rural clinics in Lesotho, Southern Afr
Microscopic diagnosis of sodium acetate-acetic acid-formalin-fixed stool samples for helminths and intestinal protozoa: a comparison among European... (Publications)
Clin Microbiol InfectAbstract The present study aimed to compare the diagnostic performance of different European reference laboratories in diagnosing helminths and intestinal protozoa, using an ether
Spatial air pollution modelling for a West-African town (Publications)
Land use regression (LUR) modelling is a common approach used in European and Northern American epidemiological studies to assess urban and traffic related air pollution exposures. Studies applying LU
Vaccination with the surface proteins MUL_2232 and MUL_3720 of <em>Mycobacterium ulcerans</em> induces antibodies but fails to provide protection... (Publications)
BACKGROUND: Buruli ulcer, caused by infection with Mycobacterium ulcerans, is a chronic ulcerative neglected tropical disease of the skin and subcutaneous tissue that is most prevalent in West African