Pharmacokinetics, <em>Trypanosoma brucei gambiense</em> efficacy and time of drug action of DB829, a preclinical candidate for treatment of second... (Publications)
Human African trypanosomiasis (HAT, sleeping sickness), a neglected tropical disease endemic to sub-Saharan Africa, is caused by the parasites Trypanosoma brucei (T. b.) gambiense and T. b. rhodesiens
Patients routinely report more symptoms to experienced field enumerators than physicians in rural Côte d'Ivoire (Publications)
Medical history-taking is among the most powerful diagnostic tools for healthcare professionals. However, its accuracy and reliability are underexplored areas. The present post-hoc study compares medi
Cotton dust, endotoxin and cancer mortality among the Shanghai textile workers cohort: a 30-year analysis (Publications)
BACKGROUND: Although occupational exposure to cotton dust and endotoxin is associated with adverse respiratory health, associations with cancer are unclear. We investigated cancer mortality in relatio
Missed opportunities among HIV-positive women to control viral replication during pregnancy and to have a vaginal delivery (Publications)
INTRODUCTION:: Most national guidelines for the prevention of mother-to-child transmission of HIV in Europe updated between 2001 and 2010 recommend vaginal deliveries for women with undetectable or ve
Air pollution and lung cancer incidence in 17 European cohorts: prospective analyses from the European Study of Cohorts for Air Pollution Effects... (Publications)
BACKGROUND: Ambient air pollution is suspected to cause lung cancer. We aimed to assess the association between long-term exposure to ambient air pollution and lung cancer incidence in European popula
Prevalence of drug-resistance mutations and HIV-1 subtypes in a HIV-1 infected COHORT in rural Tanzania (Publications)
ABSTRACT The development of resistance mutations in drug-targeted HIV-1 genes compromises the success of antiretroviral therapy (ART) programmes. Genotyping of these mutations enables adjusted therape
Efficacy and pharmacokinetics of OZ78 and MT04 against a natural infection with <em>Fasciola hepatica</em> in sheep (Publications)
Fasciolosis is a parasitosis caused by the food-borne trematode Fasciola spp. of major veterinary significance. Triclabendazole is the first line treatment in humans and animals but cases of resistanc
Differential virulence and disease progression following <em>Mycobacterium tuberculosis</em> complex infection of the common marmoset (<em>Callithrix... (Publications)
Existing small-animal models of tuberculosis (TB) rarely develop cavitary disease, limiting their value for assessing the biology and dynamics of this highly important feature of human disease. To dev
Signifikant kürzere Anästhesiezeit bei lumbaler Wirbelsäulenchirurgie: prozessanalytischer Vergleich von Spinalanästhesie und Intubationsnarkose (Publications)
INTRODUCTION: Most surgery of the lumbar spine is performed with the patient under general anesthesia (GA); however, qualitative benefits of spinal anesthesia (SA) have been reported. The goal of this