Clinical aspects and management of cutaneous leishmaniasis in rheumatoid patients treated with TNF-a antagonists (Publications)
Patients under immunosuppressive therapy with tumor necrosis factor alpha (TNF-?) antagonists are vulnerable to various opportunistic infections including leishmaniasis. We present a case series of 8
Novel 3-nitro-1<em>H</em>-1,2,4-triazole-based piperazines a nd 2-amino-1,3-benzothiazoles as antichagasic agents (Publications)
We have previously shown that 3-nitro-1H-1,2,4-triazole-based amines demonstrate significant trypanocidal activity, in particular against Trypanosoma cruzi, the causative parasite of Chagas disease. I
Synthesis and antiprotozoal activity of dicationic m-terphenyl and 1,3-dipyridylbenzene derivatives (Publications)
4,4''-Diamidino-m-terphenyl (1) and 36 analogues were prepared and assayed in vitro against T rypanosoma brucei rhodesiense , Trypanosoma cruzi , Plasmodium falciparum , and Leishmania amazonensis . T
Antigenicity and immunogenicity of a novel chimeric peptide antigen based on the <em>P. vivax</em> circumsporozoite protein (Publications)
BACKGROUND: Plasmodium vivax circumsporozoite (PvCS) protein is a major sporozoite surface antigen involved in parasite invasion of hepatocytes and is currently being considered as vaccine candidate.
High throughput multiplex assay for species identification of Papua New Guinea malaria vectors: members of the <em>Anopheles punctulatus</em>... (Publications)
Malaria and filariasis are transmitted in the Southwest Pacific region by Anopheles punctulatus sibling species including An. punctulatus, An. koliensis, the An. farauti complex 1-8 (includes An. hine
Investigation of acyclic uridine amide and 5'-amido nucleoside analogues as potential inhibitors of the <em>Plasmodium falciparum</em> dUTPase (Publications)
Previously we have shown that trityl and diphenyl deoxyuridine derivatives and their acyclic analogues can inhibit Plasmodium falciparum dUTPase (PfdUTPase). We report the synthesis of conformationall