Trisubstituted pyrimidines as efficacious and fast-acting antimalarials (Publications)
In this paper we describe the optimization of a phenotypic hit against Plasmodium falciparum, based on a trisubstituted pyrimidine scaffold. This led to compounds with good pharmacokinetics and oral a
Antimalarial spiro-bridged 1,2-dioxolanes via intramolecular addition of peroxycarbenium ions to C-C double bonds (Publications)
Several 1,2-dioxolanes embedded in a rigid spiro-bridge framework fused with a built-in UV chromophore were synthesized through intramolecular [3+2] addition of in situ generated peroxycarbenium ions
HIV-related travel restrictions: trends and country characteristics (Publications)
INTRODUCTION: Increasingly, HIV-seropositive individuals cross international borders. HIV-related restrictions on entry, stay, and residence imposed by countries have important consequences for this m
Bayesian first order auto-regressive latent variable models for multiple binary sequences (Publications)
Longitudinal clinical trials often collect long sequences of binary data monitoring a disease process over time. Our application is a medical study conducted in the US by the Veterans Administration C