Reasons for prehospital delay in acute ischemic stroke (Publications)
Background Prehospital delay reduces the proportion of patients with stroke treated with recanalization therapies. We aimed to identify novel and modifiable risk factors for prehospital delay. Methods
Exogenous iron increases fasciocidal activity and hepatocellular toxicity of the synthetic endoperoxides OZ78 and MT04 (Publications)
The synthetic peroxides OZ78 and MT04 recently emerged as fasciocidal drug candidates. However, the effect of iron on fasciocidal activity and hepatocellular toxicity of these compounds is unknown. We
Animal-assisted therapy for patients in a minimally conscious state: a randomized two treatment multi-period crossover trial (Publications)
OBJECTIVE: To investigate if animal-assisted therapy (AAT) leads to higher consciousness in patients in a minimally conscious state during a therapy session, measured via behavioral reactions, heart r
Research and implementation lessons learned from a youth-targeted digital health randomized controlled trial (the ARMADILLO Study) (Publications)
BACKGROUND: Evidence is lacking on the efficacy of sexual and reproductive health (SRH) communication interventions for youth (aged 15-24 years), especially from low- and middle-income countries. Ther
Case report: human subcutaneous sparganosis in a Thai migrant (Publications)
Human sparganosis is a cestode infection which is neglected as a differential diagnosis outside endemic countries. Diagnosis and therapy may be challenging depending on the clinical presentation and a
Infected erythrocyte-derived extracellular vesicles alter vascular function via regulatory Ago2-miRNA complexes in malaria (Publications)
Malaria remains one of the greatest public health challenges worldwide, particularly in sub-Saharan Africa. The clinical outcome of individuals infected with Plasmodium falciparum parasites depends on
Diversity-oriented synthesis yields novel multistage antimalarial inhibitors (Publications)
Antimalarial drugs have thus far been chiefly derived from two sources-natural products and synthetic drug-like compounds. Here we investigate whether antimalarial agents with novel mechanisms of acti
<em>Plasmodium</em> gametocytes display homing and vascular transmigration in the host bone marrow (Publications)
Transmission of Plasmodium parasites to the mosquito requires the formation and development of gametocytes. Studies in infected humans have shown that only the most mature forms of Plasmodium falcipar
A novel lineage of ceftriaxone-resistant <em>Salmonella </em>Typhi from India that is closely related to XDR <em>S</em>. Typhi found in Pakistan (Publications)
Two MDR Salmonella Typhi isolates from India were found by whole genome sequencing to be closely related to the 2016 XDR S. Typhi outbreak strain from Pakistan. The Indian isolates have no chromosomal