Novel synthetic route for antimalarial benzo[a]phenoxazine derivative SSJ-183 and two active metabolites (Publications)
A productive synthesis of benzo[a]phenoxazine derivative SSJ-183 (1), a promising lead for antimalarial agents, was developed using a one pot procedure. Furthermore, N-deethylated metabolite 3 and bis
KAF156 is an antimalarial clinical candidate with potential for use in prophylaxis, treatment and prevention of disease transmission (Publications)
Renewed global efforts toward malaria eradication have highlighted the need for novel antimalarial agents with activity against multiple stages of the parasite life-cycle. We have previously reported
Evaluation of Turkish seaweeds for antiprotozoal, antimycobacterial and cytotoxic activities (Publications)
As part of our continuing research on seaweeds, crude MeOH extracts of two green, three brown and six red algae collected from Marmara, Black, Aegean and Mediterranean Seas were screened. Four parasit
<em>Trypanosoma brucei</em> aquaglyceroporin 2 is a high-affinity transporter for pentamidine and melaminophenyl arsenic drugs and the main genetic... (Publications)
OBJECTIVES: Trypanosoma brucei drug transporters include the TbAT1/P2 aminopurine transporter and the high-affinity pentamidine transporter (HAPT1), but the genetic identity of HAPT1 is unknown. We re
Convergent methods assessing bone growth in an experimental model at dental implants in the minipig (Publications)
Implant dentistry demonstrated its reliability in treating successfully an increased amount of patients with dental implants exhibiting hydrophilic (modSLA) or non-hydrophilic (SLA) surfaces. Objectiv
Development of land use regression models for elemental, organic carbon, PAH and hopanes/steranes in 10 ESCAPE/TRANSPHORM European study areas (Publications)
Land use regression (LUR) models have been used to model concentrations of mainly traffic related air pollutants (nitrogen oxides (NOx), particulate matter (PM) mass or absorbance). Few LUR models are
<em>Schistosomiasis mansoni</em> in the hamster: cellular and humoral immune responses to soluble egg antigens (SEA) (Publications)
Cellular and humoral immune responses to soluble egg antigens (SEA) were studied in the course of Schistosoma mansoni infection in the hamster. No immune response to SEA could be detected before the p
Studies on <em>Trypanosoma (Nannomonas) congolense</em> IV. Experimental immunization of mice against tsetse fly challenge (Publications)
Groups of mice were exposed to multiple bites by tsetse flies (Glossina morsitans morsitans) infected with a clone of Trypanosoma congolense spread over a periof of 8 days. The mice were subsequently