Measles in Papua New Guinea: an age-specific serological survey (Publications)
We aimed to determine the proportion of the population in Madang (Papua New Guinea) immune to measles infection by age groups, with respect to immunization status and study location, using dried blood
Binding to large enzyme pockets: small-molecule inhibitors of trypanothione reductase (Publications)
The causative agents of the parasitic disease human African trypanosomiasis belong to the family of trypanosomatids. These parasitic protozoa exhibit a unique thiol redox metabolism that is based on t
Differences in conformational dynamics between <em>Plasmodium falciparum</em> and human Hsp90 orthologues enable the structure-based discovery of... (Publications)
The high sequence conservation of druggable pockets of closely related proteins can make it challenging to develop selective inhibitors. We designed a new drug discovery approach that exploits both th
A profile of travelers - an analysis from a large Swiss travel clinic (Publications)
BACKGROUND: Globally, the Swiss have one of the highest proportions of the population traveling to tropical and subtropical countries. Large travel clinics serve an increasing number of customers with
Fabclavines: bioactive peptide-polyketide-polyamino hybrids from <em>Xenorhabdus</em> (Publications)
The structure of the fabclavines-unique mixtures of nonribosomally derived peptide-polyketide hybrids connected to an unusual polyamino moiety-has been solved by detailed NMR and MS methods. These com
Genome profiling of sterol synthesis shows convergent evolution in parasites and guides chemotherapeutic attack (Publications)
Sterols are an essential class of lipids in eukaryotes, where they serve as structural components of membranes and play important roles as signaling molecules. Sterols are also of high pharmacological
Investigating the spill-over hypothesis: analysis of the association between local inflammatory markers in sputum and systemic inflammatory mediators... (Publications)
Exposure to air pollutants represents a risk factor not only for respiratory diseases and lung cancer, but also for cardiometabolic diseases. It has been hypothesised that local inflammation in the lu
Global, regional, and national levels and causes of maternal mortality during 1990-2013: a systematic analysis for the Global Burden of Disease Study... (Publications)
BACKGROUND: The fifth Millennium Development Goal (MDG 5) established the goal of a 75% reduction in the maternal mortality ratio (MMR; number of maternal deaths per 100 000 livebirths) between 1990 a