Longitudinal change of prebronchodilator spirometric obstruction and health outcomes: results from the SAPALDIA cohort (Publications)
Background Understanding the prognostic meaning of early stages of chronic obstructive pulmonary disease (COPD) in the general population is relevant for discussions about underdiagnosis. To date, COP
Integration of genome-wide association studies with biological knowledge identifies six novel genes related to kidney function (Publications)
In conducting genome-wide association studies (GWAS), analytic approaches leveraging biologic information may further understanding of the pathophysiology of clinical traits. To discover novel associa
Multiple loci associated with indices of renal function and chronic kidney disease (Publications)
Chronic kidney disease (CKD) has a heritable component and is an important global public health problem because of its high prevalence and morbidity. We conducted genome-wide association studies (GWAS
Gender differences in prevalence, diagnosis and incidence of allergic and non-allergic asthma: a population-based cohort (Publications)
BackgroundAlthough women with severe non-allergic asthma may represent a substantial proportion of adults with asthma in clinical practice, gender differences in the incidence of allergic and non-alle
HMOX1 and GST variants modify attenuation of FEF25-75% decline due to PM10 reduction (Publications)
Reduced exposure to particulate matter with a 50% cut-off aerodynamic diameter of 10 microm (PM(10)) attenuated age-related lung function decline in our cohort, particularly in the small airways. We h
Spatial variation of PM elemental compositon between and within 20 European study areas - results of the ESCAPE project (Publications)
An increasing number of epidemiological studies suggest that adverse health effects of air pollution may be related to particulate matter (PM) composition, particularly trace metals. However, we lack
Air pollution and diabetes association: modification by type 2 diabetes genetic risk score (Publications)
Exposure to ambient air pollution (AP) exposure has been linked to type 2 diabetes (T2D) risk. Evidence on the impact of T2D genetic variants on AP susceptibility is lacking. Compared to single varian
Association between ambient air pollution and diabetes mellitus in Europe and North America: systematic review and meta-analysis (Publications)
BACKGROUND: Air pollution is hypothesized to be a risk factor for diabetes. Epidemiological evidence is inconsistent and has not been systematically evaluated. OBJECTIVES: We systematically reviewed e
Air pollution and atherosclerosis: a cross-sectional analysis of four European cohort studies in the ESCAPE study (Publications)
BACKGROUND: In four European cohorts, we investigated the cross-sectional association between long-term exposure to air pollution and intima-media thickness of the common carotid artery (CIMT), a pre-
Assessing seasonal variations and age patterns in mortality during the first year of life in Tanzania (Publications)
Lack of birth and death registries in most of developing countries, particularly those in sub-Saharan Africa led to the establishment of Demographic Surveillance Systems (DSS) sites which monitor larg