DNA replication fidelity in <em>Mycobacterium tuberculosis</em> is mediated by an ancestral prokaryotic proofreader (Publications)
The DNA replication machinery is an important target for antibiotic development in increasingly drug-resistant bacteria, including Mycobacterium tuberculosis. Although blocking DNA replication leads t
MMP-1 and -3 promoter variants are indicative of a common susceptibility for skin and lung aging: results from a cohort of elderly women (SALIA) (Publications)
Studies have indicated that there may be a smoking-dependent association between skin wrinkling and airflow obstruction of the lung. It was suggested that this association might be because of an under
6-Arylpyrazine-2-carboxamides: a new core for <em>Trypanosoma brucei</em> inhibitors (Publications)
From a whole-organism high throughput screen of approximately 87,000 compounds against Trypanosoma brucei brucei, we recently identified eight new unique compounds for the treatment of human African t
Meta-analysis identifies seven susceptibility loci involved in the atopic march (Publications)
Eczema often precedes the development of asthma in a disease course called the 'atopic march'. To unravel the genes underlying this characteristic pattern of allergic disease, we conduct a multi-stage
Pharmacological effects of primaquine ureas and semicarbazides on the CNS in mice and antimalarial activity in vitro (Publications)
New primaquine (PQ) urea and semicarbazide derivatives 1-4 were screened for the first time for CNS and antimalarial activity. Behavioural tests were performed on mice. In vitro cytotoxicity on L-6 ce
The elderly, the young and the pregnant traveler - a retrospective data analysis from a large Swiss Travel Center with a special focus on malaria... (Publications)
BACKGROUND: Vulnerable individuals such as elderly, children/adolescents and pregnant/breastfeeding women increasingly travel overseas. We describe the travel and vaccination patterns of these groups
Costing RTS,S introduction in Burkina Faso, Ghana, Kenya, Senegal, Tanzania, and Uganda: a generalizable approach drawing on publicly available data (Publications)
Recent results from the phase 3 trial of RTS,S/AS01 malaria vaccine show that the vaccine induced partial protection against clinical malaria in infants and children; given the high burden of the dise
Antiprotozoal effect of <em>Artemisia indica</em> extracts and essential oil (Publications)
Diverse solvent extracts of Artemisia indica leaves originating from the West Bengal region (India) were assessed for the content of artemisinin and characteristic Artemisia polymethoxyflavonoids, nam