QSAR guided synthesis of simplified antiplasmodial analogs of naphthylisoquinoline alkaloids (Publications)
Naphthylisoquinoline alkaloids have attracted considerable interest because of their intriguing structure, their unique biosynthetic origin, and their biological activities against several pathogens c
Jozimine A2: the first dimeric dioncophyllaceae-type naphthylisoquinoline alkaloid, with three chiral axes and high antiplasmodial activity (Publications)
A new dimeric naphthylisoquinoline alkaloid, jozimine A(2) (2), was isolated from the root bark of an Ancistrocladus species from the Democratic Republic of Congo. Its absolute stereostructure was det
Measuring and validating physical activity and sedentary behavior comparing a parental questionnaire to accelerometer data and diaries (Publications)
Accurately measuring children's physical activity and their sedentary behavior is challenging. The present study compared 189 parental responses to a questionnaire surveying physical activity and sede
Synthesis, structure-activity relationship, and mode-of-action studies of antimalarial reversed chloroquine compounds (Publications)
We have previously shown that a "reversed chloroquine (RCQ)" molecule, composed of a chloroquine-like moiety and a resistance reversal-like moiety, can overcome chloroquine resistance in P. falciparum
Chemotherapy against human African trypanosomiasis: is there a road to success? (Publications)
SUMMARYFor over fifty years, human African trypanosomiasis (HAT, sleeping sickness) has been treated with suramin, pentamidine and the very toxic organo-arsenical melarsoprol that was the only drug av
Growth of mature beech in relation to ozone and nitrogen deposition: an epidemiological approach (Publications)
Stem increment of mature Fagus sylvatica L. from 57 plots in Switzerland was analysed with respect to environmental factors using multilinear regression. Nitrogen (N) deposition was positively correla