Programmatically selected multidrug-resistant strains drive the emergence of extensively drug-resistant Tuberculosis in South Africa (Publications)
BACKGROUND: South Africa shows one of the highest global burdens of multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB). Since 2002, MDR-TB in South Africa has been treate
Scope and limits of an anamnestic questionnaire in a control-induced low-endemicity helminthiasis setting in south-central Côte d'Ivoire (Publications)
BACKGROUND: Schistosomiasis and soil-transmitted helminthiasis are two high-burden neglected tropical diseases. In highly endemic areas, control efforts emphasize preventive chemotherapy. However, as
Reduced risk of <em>Plasmodium vivax</em> malaria in Papua New Guinean children with Southeast Asian ovalocytosis in two cohorts and a case-control... (Publications)
BACKGROUND: The erythrocyte polymorphism, Southeast Asian ovalocytosis (SAO) (which results from a 27-base pair deletion in the erythrocyte band 3 gene, SLC4A1Delta27) protects against cerebral malari
The elusive meningococcal meningitis serogroup: a systematic review of serogroup B epidemiology (Publications)
BACKGROUND: Invasive meningococcal disease (IMD), is a widely distributed, complex human disease affecting all age categories. The causative agent, Neisseria meningitidis, is spread through aerosol re
Advancing drug innovation for neglected diseases-criteria for lead progression (Publications)
The current drug R&D pipeline for most neglected diseases remains weak, and unlikely to support registration of novel drug classes that meet desired target product profiles in the short term. This cal
Determinants of the cost-effectiveness of intermittent preventive treatment for malaria in infants and children (Publications)
BACKGROUND: Trials of intermittent preventive treatment in infants (IPTi) and children (IPTc) have shown promising results in reducing malaria episodes but with varying efficacy and cost-effectiveness
Safety of falciparum malaria diagnostic strategy based on rapid diagnostic tests in returning travellers and migrants: a retrospective study (Publications)
BACKGROUND: Rapid diagnostic tests for malaria (RDT) allow accurate diagnosis and prompt treatment. Validation of their usefulness in travellers with fever was needed. The safety of a strategy to diag
Interactions and potential implications of <em>Plasmodium falciparum</em>-hookworm coinfection in different age groups in south-central Côte... (Publications)
BACKGROUND: Given the widespread distribution of Plasmodium and helminth infections, and similarities of ecological requirements for disease transmission, coinfection is a common phenomenon in sub-Sah
Exposure to radiofrequency electromagnetic fields and sleep quality: a prospective cohort study (Publications)
BACKGROUND: There is persistent public concern about sleep disturbances due to radiofrequency electromagnetic field (RF-EMF) exposure. The aim of this prospective cohort study was to investigate wheth