Should deep-sequenced amplicons become the new gold-standard for analysing malaria drug clinical trials? (Publications)
Background. Regulatory clinical trials are required to ensure the continued supply and deployment of effective antimalarial drugs. Patient follow-up in such trials typically lasts several weeks as the
Mechanistic within-host models of the asexual <em>Plasmodium falciparum</em> infection: a review and analytical assessment (Publications)
BACKGROUND: Malaria blood-stage infection length and intensity are important drivers of disease and transmission; however, the underlying mechanisms of parasite growth and the host's immune response d
Efficacy of triclabendazole and albendazole against <em>Fasciola </em>spp. infection in cattle in Côte d'Ivoire: a randomised blinded trial (Publications)
Triclabendazole is the anthelminthic of choice for the treatment of fascioliasis, however, it is not yet registered in many countries. Therefore, we investigated the efficacy of a single-dose of tricl
Enantiospecific antitrypanosomal<em> in vitro</em> activity of eflornithine (Publications)
The polyamine synthesis inhibitor eflornithine is a recommended treatment for the neglected tropical disease Gambian human African trypanosomiasis in late stage. This parasitic disease, transmitted by
Expression dysregulation as a mediator of fitness costs in antibiotic resistance (Publications)
Antimicrobial resistance (AMR) poses a threat to global health and the economy. Rifampicin-resistant Mycobacterium tuberculosis accounts for a third of the global AMR burden. Gaining the upper hand on
"Linkage to care" among people living with HIV - definition in the era of "universal test and treat" in a sub-Sahara African setting (Publications)
BACKGROUND: Prompt linkage to human immunodeficiency virus (HIV) care after diagnosis is of utmost importance for individual health and reduction of HIV transmission. Different definitions for “linkag
Boswellic acids show <em>in vitro</em> activity against <em>Leishmania donovani</em> (Publications)
In continuation of our search for leads from medicinal plants against protozoal pathogens, we detected antileishmanial activity in polar fractions of a dichloromethane extract from Boswellia serrata r
Antiprotozoal <em>Nor</em>-triterpene alkaloids from <em>Buxus sempervirens</em> L (Publications)
Malaria and human African trypanosomiasis (HAT; sleeping sickness) are life-threatening tropical diseases caused by protozoan parasites. Due to limited therapeutic options, there is a compelling need