Cytochrome P450-mediated metabolism and CYP Inhibition for the synthetic peroxide antimalarial OZ439 (Publications)
OZ439 is a potent synthetic ozonide evaluated for the treatment of uncomplicated malaria. The metabolite profile of OZ439 was characterized in vitro using human liver microsomes combined with LC/MS-MS
Determinants of safety climate at primary care level in Ghana, Malawi and Uganda: a cross-sectional study across 138 selected primary healthcare... (Publications)
BACKGROUND: Safety climate is an essential component of achieving Universal Health Coverage, with several organisational, unit or team-level, and individual health worker factors identified as influen
The role of extreme temperature in cause-specific acute cardiovascular mortality in Switzerland: a case-crossover study (Publications)
Since the 2003 heatwave in Europe, evidence has been rapidly increasing on the association between extreme temperature and all-cause mortality. Little is known, however, about cause-specific cardiovas
Synthesis, <em>in vitro</em> antiprotozoal activity, molecular docking and molecular dynamics studies of some new monocationic guanidinobenzimidazoles (Publications)
A series of monocationic new guanidinobenzimidazole derivatives were prepared in a four step process starting from 2-nitro-1,4-phenylendiamine. Their antiparasitic activity against Plasmodium falcipar
Health impacts of industrial mining on surrounding communities: local perspectives from three sub-Saharan African countries (Publications)
Industrial mining projects can play an important role in global sustainable development if associated health risks are minimised and opportunities maximised. While a broad body of evidence from quanti
Long-term neurological and psychological distress symptoms among smallholder farmers in Costa Rica with a history of acute pesticide poisoning (Publications)
Studies suggest that acute pesticide poisonings (APP) may be linked with long-term neurological effects. To examine long-term neurological and psychological distress symptoms associated with having ex
Perception of cure among leprosy patients post completion of multi-drug therapy (Publications)
BACKGROUND: Leprosy is a treatable disease; however, the release from treatment after completion of multidrug therapy (MDT) often does not equal absence of health problems. Consequently, sequelae inte
TIDE analysis of <em>Cryptosporidium </em>infections by <em>gp60 </em>typing reveals obscured mixed infections (Publications)
BACKGROUND: Cryptosporidiosis is a parasitic disease associated with potentially fatal diarrhea. The most used method in Cryptosporidium subtyping is based on the glycoprotein gene gp60. Each infectio
Whole-genome sequence-informed MALDI-TOF MS diagnostics reveal importance of <em>Klebsiella oxytoca</em> group in invasive infections: a retrospective... (Publications)
BACKGROUND: Klebsiella spp. are opportunistic pathogens which can cause severe infections, are often multi-drug resistant and are a common cause of hospital-acquired infections. Multiple new Klebsiell
Same-day antiretroviral therapy initiation for people living with HIV who have tuberculosis symptoms: a systematic review (Publications)
OBJECTIVES: Tuberculosis symptoms are very common among people living with HIV (PLHIV) initiating antiretroviral therapy (ART), are not specific for tuberculosis disease and may result in delayed ART