Gill tissue lipids of salmon (Salmo salar L.) presmolts and smolts from anadromous and landlocked populations (Publications)
Composition of membrane lipids from the gills of juvenile Atlantic salmon (Salmo salar) in presmolt and smolt phases of development were compared among anadromous and non-anadromous populations. Three
Describing the evolution of medication nonadherence from pretransplant until 3 years post-transplant and determining pretransplant medication... (Publications)
Although medication nonadherence (MNA) is a major risk factor for poor outcomes, the evolution of MNA from pre- to 3 years post-transplant among the four major organ transplant groups remains unknown.
Binding to large enzyme pockets: small-molecule inhibitors of trypanothione reductase (Publications)
The causative agents of the parasitic disease human African trypanosomiasis belong to the family of trypanosomatids. These parasitic protozoa exhibit a unique thiol redox metabolism that is based on t
Differences in conformational dynamics between <em>Plasmodium falciparum</em> and human Hsp90 orthologues enable the structure-based discovery of... (Publications)
The high sequence conservation of druggable pockets of closely related proteins can make it challenging to develop selective inhibitors. We designed a new drug discovery approach that exploits both th
A profile of travelers - an analysis from a large Swiss travel clinic (Publications)
BACKGROUND: Globally, the Swiss have one of the highest proportions of the population traveling to tropical and subtropical countries. Large travel clinics serve an increasing number of customers with
Fabclavines: bioactive peptide-polyketide-polyamino hybrids from <em>Xenorhabdus</em> (Publications)
The structure of the fabclavines-unique mixtures of nonribosomally derived peptide-polyketide hybrids connected to an unusual polyamino moiety-has been solved by detailed NMR and MS methods. These com
Genome profiling of sterol synthesis shows convergent evolution in parasites and guides chemotherapeutic attack (Publications)
Sterols are an essential class of lipids in eukaryotes, where they serve as structural components of membranes and play important roles as signaling molecules. Sterols are also of high pharmacological