Ten-year follow-up of cluster-based asthma phenotypes in adults: a pooled analysis of three cohorts (Publications)
Rationale: The temporal stability of adult asthma phenotypes identified using clustering methods has never been addressed. Longitudinal cluster-based methods may provide novel insights in the study of
Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction (Publications)
RATIONALE: Genome-wide association studies (GWAS) have identified loci influencing lung function, but fewer genes influencing chronic obstructive pulmonary disease (COPD) are known. OBJECTIVES: Perfor
alpha1-Antitrypsin deficiency and lung disease: risk modification by occupational and environmental inhalants (Publications)
Chronic obstructive pulmonary disease (COPD) is a prevalent and preventable disease associated with high morbidity and mortality. Severe and intermediate alpha1-antitrypsin (AAT) deficiency (serum lev
What physical activity surveillance needs: validity of a single-item questionnaire (Publications)
BACKGROUND: Self-report instruments to assess physical activity are still the most feasible option in many population-wide surveys, and often need to be very short owing to resource constraints. The a
Western European land use regression incorporating satellite- and ground-based measurements of NO2 and PM10 (Publications)
Land use regression (LUR) models typically investigate within-urban variability in air pollution. Recent improvements in data quality and availability, including satellite-derived pollutant measuremen
A comprehensive evaluation of potential lung function associated genes in the SpiroMeta general population sample (Publications)
RATIONALE: Lung function measures are heritable traits that predict population morbidity and mortality and are essential for the diagnosis of chronic obstructive pulmonary disease (COPD). Variations i
Genome-wide association study identifies five loci associated with lung function (Publications)
Pulmonary function measures are heritable traits that predict morbidity and mortality and define chronic obstructive pulmonary disease (COPD). We tested genome-wide association with forced expiratory
Is diabetes a risk factor for a severe clinical presentation of dengue? Review and meta-analysis (Publications)
BACKGROUND: The mean age of acute dengue has undergone a shift towards older ages. This fact points towards the relevance of assessing the influence of age-related comorbidities, such as diabetes, on
The relevance of commuter and work/school exposure in an epidemiological study on traffic-related air pollution (Publications)
Exposure during transport and at non-residential locations is ignored in most epidemiological studies of traffic-related air pollution. We investigated the impact of separately estimating NO2 long-ter