Investigating sulfoxide-to-sulfone conversion as a prodrug strategy for a phosphatidylinositol 4-kinas inhibitor in a humanized mouse model of malaria (Publications)
The in vivo antimalarial efficacies of two PI4K inhibitors, a 3,5-diaryl-2-aminopyrazine sulfoxide and its corresponding sulfone metabolite, were evaluated in the NOD-scid IL2Rgamma(null) (NSG) murine
Social resilience and mental health among Eritrean asylum-seekers in Switzerland (Publications)
Eritreans comprise the largest group of asylum-seekers in Switzerland. Gaining recognized refugee status can take up to 36 months, during which time asylum-seekers live in a state of legal limbo, inte
Transfer of enteric viruses (adenovirus and coxsackievirus) and bacteriophage (MS2) from liquid to human skin (Publications)
Indirect exposure to waterborne viruses increases risk of infection, especially amongst children with frequent hand-to-mouth contacts. Here, we quantified the transfer of one bacteriophage (MS2) and t
Extrapolation of praziquantel pharmacokinetics to a pediatric population: a cautionary tale (Publications)
L-praziquantel (PZQ) pharmacokinetic data were analyzed from two relative bioavailability Phase 1 studies in adult, healthy subjects with two new oral dispersion tablet (ODT) formulations of L-PZQ adm
Double trouble: visceral leishmaniasis in twins after traveling to Tuscany - a case report (Publications)
BACKGROUND: Leishmaniasis is endemic in many countries worldwide, with a prevalence of 12 million people infected, and an estimated annual incidence of 500 000 visceral leishmaniasis cases. In Europe
High genetic diversity in the <em>Dirofilaria repens</em> species complex revealed by mitochondrial genomes of feline microfilaria samples from... (Publications)
Dirofilaria repens is a zoonotic, mosquito-borne filaria infecting carnivores, particularly dogs. It is expanding its range in Europe but epidemiological information is sparse for other Eurasian regio
Sensitivity of the point-of-care circulating cathodic antigen urine cassette test for diagnosis of <em>Schistosoma mansoni</em> in low-endemicity... (Publications)
The sensitivity of a point-of-care circulating cathodic antigen (POC-CCA) urine cassette test for diagnosis of Schistosoma mansoni in low-endemicity settings is poorly understood. We conducted a cross