Lead optimization of a pyrrole-based dihydroorotate dehydrogenase inhibitor series for the treatment of malaria (Publications)
Malaria puts at risk nearly half the world's population and causes high mortality in sub-Saharan Africa, while drug resistance threatens current therapies. The pyrimidine biosynthetic enzyme dihydroor
Assessment of diabetes and prediabetes prevalence and predictors by HbA1c in a population from sub-Saharan Africa with a high proportion of anemia: a... (Publications)
INTRODUCTION: Epidemiological data about diabetes mellitus (DM) for sub-Saharan Africa (SSA) are scarce and the utility of glycated hemoglobin (HbA1c) to diagnose DM is uncertain in African population
Digital multiplex ligation assay for highly multiplexed screening of beta-lactamase-encoding genes in bacterial isolates (Publications)
Increasing incidence of antibiotic resistance in clinical and environmental settings calls for increased scalability in their surveillance. Current screening technologies are limited by the number of
Contribution of vaccination to improved survival and health: modelling 50 years of the Expanded Programme on Immunization (Publications)
BACKGROUND: WHO, as requested by its member states, launched the Expanded Programme on Immunization (EPI) in 1974 to make life-saving vaccines available to all globally. To mark the 50-year anniversar
Pre-pregnancy body mass index and caesarean section in Andean women in Peru: a prospective cohort study (Publications)
BACKGROUND: During the last two decades, Caesarean section rates (C-sections), overweight and obesity rates increased in rural Peru. We examined the association between pre-pregnancy body mass index (
The effects of radiofrequency electromagnetic fields exposure on human self-reported symptoms: a systematic review of human experimental studies (Publications)
BACKGROUND: The technological applications of radiofrequency electromagnetic fields (RF-EMF) have been steadily increasing since the 1950s exposing large proportions of the population. The World Healt
A paradigm for Africa-centric vaccine development in Equatorial Guinea (Publications)
The Equatorial Guinea Malaria Vaccine Initiative (EGMVI) highlights how long-term African government and international energy industry investment, plus novel partnerships, can enable clinical developm
The Tools for Integrated Management of Childhood Illness (TIMCI) study protocol: a multi-country mixed-method evaluation of pulse oximetry and... (Publications)
Effective and sustainable strategies are needed to address the burden of preventable deaths among children under-five in resource-constrained settings. The Tools for Integrated Management of Childhood
<em>Plasmodium falciparum pfhrp2</em> and <em>pfhrp3</em> gene deletions among patients enrolled at 100 health facilities throughout Tanzania:... (Publications)
Plasmodium falciparum with the histidine rich protein 2 gene (pfhrp2) deleted from its genome can escape diagnosis by HRP2-based rapid diagnostic tests (HRP2-RDTs). The World Health Organization (WHO)