Synthesis and antimalarial property of orally active phenoxazinium salts (Publications)
Phenoxazinium salts were found to display good antimalarial efficacy in vivo against Plasmodium berghei. Several compounds provided 100% parasitemia clearance at a dose of 20-30 mg kg-1x4 days (ip) an
Genomic deletions classify the Beijing/W strains as a distinct genetic lineage of <em>Mycobacterium tuberculosis</em> (Publications)
Beijing/W strains of Mycobacterium tuberculosis are geographically widespread and hypervirulent. To enhance our understanding of their origin and evolution, we sought phylogenetically informative larg
Relationship between <em>Mycobacterium tuberculosis</em> genotype and the clinical phenotype of pulmonary and meningeal tuberculosis (Publications)
We used large sequence polymorphisms to determine the genotypes of 397 isolates of Mycobacterium tuberculosis from human immunodeficiency virus-uninfected Vietnamese adults with pulmonary (n = 235) or
Marine natural products from the Turkish sponge <em>Agelas oroides</em> that inhibit the enoyl reductases from <em>Plasmodium falciparum</em>,<em>... (Publications)
The type II fatty acid pathway (FAS-II) is a validated target for antimicrobial drug discovery. An activity-guided isolation procedure based on Plasmodium falciparum enoyl-ACP reductase (PfFabI) enzym
Antituberculotic and antiprotozoal activities of primin, a natural benzoquinone: in vitro and in vivo studies (Publications)
Primin (=2-methoxy-6-pentylcyclohexa-2,5-diene-1,4-dione), a natural benzoquinone synthesized in our laboratory, was investigated for its in vitro antiprotozoal, antimycobacterial, and cytotoxic poten