Diaryl sulfide-based inhibitors of trypanothione reductase: inhibition potency, revised binding mode and antiprotozoal activities (Publications)
Trypanothione reductase (TR) is an essential enzyme of trypanosomatids and therefore a promising target for the development of new drugs against African sleeping sickness and Chagas' disease. Diaryl s
Synthesis of bicyclic amines and their activities against <em>Trypanosoma brucei rhodesiense</em> and <em>Plasmodium falciparum</em> K1 (Publications)
New alkenes, aziridines, and diamines were prepared from antiprotozoal 4-dialkylaminobicyclo[2.2.2]octan-2-imines to investigate the influence of several functional groups in position 2 of the ring sk
Genomic deletions classify the Beijing/W strains as a distinct genetic lineage of <em>Mycobacterium tuberculosis</em> (Publications)
Beijing/W strains of Mycobacterium tuberculosis are geographically widespread and hypervirulent. To enhance our understanding of their origin and evolution, we sought phylogenetically informative larg