Chronic age-related diseases share risk factors: do they share pathophysiological mechanisms and why does that matter? (Publications)
The World Health Organization (WHO) assigns high priority to the prevention of non-communicable age-related diseases such as heart disease, cancer, diabetes, stroke and chronic lower respiratory disea
Ambient air pollution and the progression of atherosclerosis in adults (Publications)
BACKGROUND: Cross-sectional studies suggest an association between exposure to ambient air pollution and atherosclerosis. We investigated the association between outdoor air quality and progression of
Guidance for evidence-informed policies about health systems: assessing how much confidence to place in the research evidence (Publications)
In the third paper in a three-part series on health systems guidance, Simon Lewin and colleagues explore the challenge of assessing how much confidence to place in evidence on health systems intervent
Quantifying behavioural interactions between humans and mosquitoes: Evaluating the protective efficacy of insecticidal nets against malaria... (Publications)
ABSTRACT: BACKGROUND: African malaria vectors bite predominantly indoors at night so sleeping under an Insecticide-Treated Net (ITN) can greatly reduce malaria risk. Behavioural adaptation by mosquito
Crying babies, tired mothers - challenges of the postnatal hospital stay: an interpretive phenomenological study (Publications)
ABSTRACT: BACKGROUND: According to an old Swiss proverb, "a new mother lazing in childbed is a blessing to her family". Today mothers rarely enjoy restful days after birth, but enter directly into the
Chemometric analysis of biofluids from mice experimentally infected with <em>Schistosoma mansoni</em> (Publications)
ABSTRACT: BACKGROUND: The urinary metabolic fingerprint of a patent Schistosoma mansoni infection in the mouse has been characterized using spectroscopic methods. However, the temporal dynamics of met
Comparative analysis of <em>Mycobacterium tuberculosis</em> <em>pe </em>and <em>ppe</em> genes reveals high sequence variation and an apparent absence... (Publications)
Mycobacterium tuberculosis complex (MTBC) genomes contain 2 large gene families termed pe and ppe. The function of pe/ppe proteins remains enigmatic but studies suggest that they are secreted or cell
Development of an in vitro drug screening assay using <em>Schistosoma haematobium</em> schistosomula (Publications)
ABSTRACT: BACKGROUND: The development of novel antischistosomal drugs is crucial, as currently no vaccine and only a single drug is available for the treatment of schistosomiasis. Fast and accurate in
<em>Plasmodium falciparum</em> resistance to anti-malarial drugs in Papua New Guinea: evaluation of a community-based approach for the molecular... (Publications)
BACKGROUND: Molecular monitoring of parasite resistance has become an important complementary tool in establishing rational anti-malarial drug policies. Community surveys provide a representative samp
Genome-wide identification of molecular mimicry candidates in parasites (Publications)
Among the many strategies employed by parasites for immune evasion and host manipulation, one of the most fascinating is molecular mimicry. With genome sequences available for host and parasite, mimic